Evidence map›Paper›PMID 38265104›Full record

ArticleMagnetic resonance in medicine2024

Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-

Maheen Zaidi, Junjie Ma, Binu P Thomas, Salvador Peña, Crystal E Harrison, Jun Chen, Sung-Han Lin, Kelley A Derner, Jeannie D Baxter, Jeff Liticker and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Maheen ZaidiAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Junjie MaAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Binu P ThomasAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Salvador PeñaAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Crystal E HarrisonAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jun ChenAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sung-Han LinAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-1384-4037
Kelley A DernerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jeannie D BaxterAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jeff LitickerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Craig R MalloyAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-5077-0642
Brenda Bartnik-OlsonDepartment of Radiology, Loma Linda University, Loma Linda, California, USA.
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-7404-6971
Advanced Imaging Research (United States) · USGeneral Electric (Spain) · ESLoma Linda University · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
A Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
Muscular Dystrophy Association (MDA) MDA963281NCRR NIH HHS S10 RR029119NIBIB NIH HHS P41 EB013598NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P30 DK127984NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409ODCDC CDC HHS S10 OD018468U.S. Army Medical Research Acquisition Activity USAMRAA
6 · The paper itself

Abstract

purposePyruvate, produced from either glucose, glycogen, or lactate, is the dominant precursor of cerebral oxidative metabolism. Pyruvate dehydrogenase (PDH) flux is a direct measure of cerebral mitochondrial function and metabolism. Detection of [

methodsFrom seven sedentary adults in good general health, time-resolved [

resultsIn the course of visual stimulation, the measured [

conclusionWe demonstrated the utility of

Indexed as

BicarbonatesPyruvic AcidAdultBrainCarbon IsotopesHumansLactic AcidOxidoreductasesBicarbonatesCarbon IsotopesLactic AcidOxidoreductasesPyruvic Acidbicarbonatebrain activationdissolution dynamic nuclear polarizationfMRShyperpolarized pyruvatepyruvate dehydrogenase

Identifiers

PMID38265104
PMCPMC10950523
OpenAlexW4391169738

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.