Evidence map›Paper›PMID 38265159›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Lewy body dementia: Overcoming barriers and identifying solutions.

Kanishka Agarwal, Wendi Backler, Ece Bayram, Leah Bloom, Bradley F Boeve, Jang-Ho Cha, Maria Denslow, Tanis J Ferman, Douglas Galasko, James E Galvin and 23 more

Open access · hybridAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Examining the lived experience of dementia with Lewy bodies through qualitative research: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Phase 2 study of zervimesine (CT1812) in participants with mild-to-moderate dementia with Lewy bodies (DLB).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
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  13. Lewy body dementia: Overcoming barriers and identifying solutions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 18 institutions in 2 countries.

Kanishka AgarwalThe Boston Consulting Group, Boston, Massachusetts, USA.
Wendi BacklerThe Boston Consulting Group, Boston, Massachusetts, USA.
Ece BayramParkinson and Other Movement Disorders Center, Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
Leah BloomZag Bio, Inc, Cambridge, Massachusetts, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Jang-Ho ChaLatus Bio, Cambridge, Massachusetts, USA.
Maria DenslowAlzheimer Disease and Brain Health, Eisai, Inc., Nutley, New Jersey, USA.
Tanis J FermanDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA.
Douglas GalaskoDepartment of Neurosciences, and Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, La Jolla, California, USA.
James E GalvinDepartment of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, USA.
Stephen N GompertsDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael C IrizarryAlzheimer Disease and Brain Health, Eisai, Inc., Nutley, New Jersey, USA.
Kejal KantarciDepartment of Radiology, Division of Neuroradiology, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Harsh KaushikThe Boston Consulting Group, Boston, Massachusetts, USA.
Matt KietlinskiThe Boston Consulting Group, Boston, Massachusetts, USA.
Aaron KoenigDelix Therapeutics, Bedford, Massachusetts, USA.
James B LeverenzCleveland Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Ian McKeithTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Pamela J McLeanDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Thomas J MontineDepartment of Pathology, Stanford University, Stanford, California, USA.
Sandra O MooseThe Boston Consulting Group, Boston, Massachusetts, USA.
John T O'BrienDepartment of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Valery PanierThe Boston Consulting Group, Boston, Massachusetts, USA.
Sharad RamanathanDepartments of Molecular and Cell Biology, Stem Cell and Regenerative Biology and Applied Physics, Harvard University, Cambridge, Massachusetts, USA.
Michael S RingelThe Boston Consulting Group, Boston, Massachusetts, USA.
Sonja W ScholzNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Jonnell SmallThe Boston Consulting Group, Boston, Massachusetts, USA.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Angela TaylorLewy Body Dementia Association, Lilburn, Georgia, USA.
John-Paul TaylorDepartment of Pathology, Stanford University, Stanford, California, USA.
Rebecca A WardDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6752-5600
Lisa WittenThe Boston Consulting Group, Boston, Massachusetts, USA.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Boston Engineering (United States) · USMassachusetts General Hospital · USAlzheimer’s Disease Neuroimaging Initiative · USJacksonville College · USMayo Clinic · USStanford University · USUniversity of California San Diego · USBiogen (United States) · USBrigham and Women's Hospital · USCleveland Clinic · USDementia UK · GBEpix Pharmaceuticals (United States) · USHarvard University · USManus Bio (United States) · USNational Institutes of Health · USNewcastle University · GBUniversity of Cambridge · GBUniversity of Miami · US

Funding

Project: Predicting PhenoconversionU19AG071754 · NIA · WASHINGTON UNIVERSITY · PI Aleksandar Videnovic · 2021 to 2026
$41.2M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMES B BREWER · 2019 to 2026
$34.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Dementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6M
Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics DiscoveryU01AG073323 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BEKRIS, LYNN, CHENG, FEIXIONG · 2021 to 2025
$4.0M
OXIDATIVE STRESS MITOCHONDRIAZ01AG000733 · NIA · NATIONAL INSTITUTE ON AGING · PI BOHR, VILHELM A · 1996 to 2008
$1.6M
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasR00AG073453 · NIA · UNIVERSITY OF COLORADO DENVER · PI ECE BAYRAM · 2024 to 2026
$725k
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasK99AG073453 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAYRAM, ECE · 2022 to 2023
$251k
Intramural NIH HHS Z01 AG000733Intramural NIH HHS ZIA NS003154NIA NIH HHS K99 AG073453NIA NIH HHS K99AG073453NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30AG062677NIA NIH HHS P30 AG072959NIA NIH HHS R00 AG073453NIA NIH HHS U01 AG073323NIA NIH HHS U01NS100620NIA NIH HHS U19 AG071754NIA NIH HHS U19AG071754NIH HHS P30AG062677NIH HHS P30AG072959NIH HHS U01AG0733NIH HHS U01NS100610NIH HHS U01NS100620NIH HHS U19AG071754NIH HHS ZIANS003154NINDS NIH HHS U01 NS100610NINDS NIH HHS U01 NS100620NINDS NIH HHS ZIANS003154
6 · The paper itself

Abstract

Despite its high prevalence among dementias, Lewy body dementia (LBD) remains poorly understood with a limited, albeit growing, evidence base. The public-health burden that LBD imposes is worsened by overlapping pathologies, which contribute to misdiagnosis, and lack of treatments. For this report, we gathered and analyzed public-domain information on advocacy, funding, research outputs, and the therapeutic pipeline to identify gaps in each of these key elements. To further understand the current gaps, we also conducted interviews with leading experts in regulatory/governmental agencies, LBD advocacy, academic research, and biopharmaceutical research, as well as with funding sources. We identified wide gaps across the entire landscape, the most critical being in research. Many of the experts participated in a workshop to discuss the prioritization of research areas with a view to accelerating therapeutic development and improving patient care. This white paper outlines the opportunities for bridging the major LBD gaps and creates the framework for collaboration in that endeavor. HIGHLIGHTS: A group representing academia, government, industry, and consulting expertise was convened to discuss current progress in Dementia with Lewy Body care and research. Consideration of expert opinion,natural language processing of the literature as well as publicly available data bases, and Delphi inspired discussion led to a proposed consensus document of priorities for the field.

Indexed as

Lewy Body DiseaseHumansfunding sourcesLewy body dementianatural language processingresearch trends

Identifiers

PMID38265159
PMCPMC10942666
OpenAlexW4391169544

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.