Evidence map›Paper›PMID 38275620›Full record

ArticleGenes2024

Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.

Francesco Savino, Allegra Sardo, Stefano Gambarino, Maddalena Dini, Anna Clemente, Anna Pau, Ilaria Galliano, Massimiliano Bergallo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesco SavinoEarly Infancy Special Care Unit, Regina Margherita Children Hospital, A.O.U. Città della Salute e della Scienza di Torino, 10126 Torino, Italy.ORCID 0000-0001-9163-1016
Allegra SardoEarly Infancy Special Care Unit, Regina Margherita Children Hospital, A.O.U. Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
Stefano GambarinoDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.
Maddalena DiniDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.
Anna ClementeDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.
Anna PauDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.
Ilaria GallianoDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.
Massimiliano BergalloDepartment of Public Health and Pediatric Sciences, Immunopathology Laboratory, Medical School, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-9291-1332
University of Turin · ITOspedale Regina Margherita · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been proven that single-nucleotide polymorphisms (SNPs) in LEP and LEPR genes could predispose individuals to an increased risk of pregnancy adverse outcomes (PAOs) such as recurrent pregnancy loss (RPL) and pre-eclampsia. Preterm birth (PTB) is the leading cause of infant mortality. We decided to investigate the correlation between PTB and LEP and LEPR SNPs. The study cohort included families who underwent spontaneous PTB and control samples of families who had at-term-born (≥37 weeks of gestational age) children. Swabs were performed by rubbing the sticky end for about 30 s on the gum and on the inside of the cheek, allowing us to collect the flaking cells of the oral mucosa. Genotyping of the three SNPs-LEPRA668G, LEPG2548A and A19G-was carried out via an ARMS-MAMA real-time PCR procedure, as previously described. Regarding LEPG2548A, we found that the most expressed genotype in infants both in the preterm and the at-term group was AG; however, we did not discover any statistically significant difference (

Indexed as

Premature BirthChildFemaleHumansInfantInfant, NewbornLeptinParentsPolymorphism, Single NucleotidePregnancyReceptors, LeptinLEP protein, humanLeptinReceptors, Leptinbuccal swabgeneticsinfantsleptinleptin receptorparentspolymorphismspreterm birth

Identifiers

PMID38275620
PMCPMC10815013
OpenAlexW4391098882

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.