Evidence map›Paper›PMID 38277098›Full record

ReviewCurrent HIV/AIDS reports2024

Antiretroviral Therapy in Pregnancy: A 2023 Review of the Literature.

Alison N Goulding, Kasey Meeks, Lena Shay, Sarah Casey, Colton Applegarth, Jennifer McKinney

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alison N GouldingDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Kasey MeeksSchool of Medicine, Saint Louis University, Saint Louis, MO, USA.
Lena ShayDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Sarah CaseySchool of Medicine, Baylor College of Medicine, Houston, TX, USA.
Colton ApplegarthSchool of Medicine, University of California San Diego, San Diego, CA, USA.
Jennifer McKinneyDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. Jennifer.mckinney@bcm.edu.
Baylor College of Medicine · USSaint Louis University · USUniversity of California San Diego · US

Funding

Baylor College of Medicine and Texas Children's WRHR Center of ExcellenceK12HD103087 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI BELFORT, MICHAEL A · 2020 to 2024
$1.2M
NICHD NIH HHS K12 HD103087
6 · The paper itself

Abstract

purpose of reviewSelection of antiretroviral therapy during pregnancy must consider maternal physiology and resulting pharmacokinetic changes in pregnancy, resistance and efficacy profiles, tolerability and frequency of adverse effects, teratogenicity, and maternal, neonatal, and pregnancy outcomes. The objective of this review is to summarize the underlying data that informs the current clinical perinatal guidelines in the USA. RECENT

findingsData now supports the use of dolutegravir at all stages of pregnancy with no significant increase in neural tube defects. Safety and pharmacokinetic data on newer antiretroviral medications in pregnancy continue to lag behind the general population. While there are multiple safety and tolerability concerns with older regimens, there are now multiple options of regimens that are highly efficacious and have good safety data in pregnancy. Most pregnant patients who are virally suppressed on a well-tolerated regimen are able to safely continue those medications during pregnancy.

Indexed as

Anti-HIV AgentsHIV InfectionsPregnancy Complications, InfectiousAnti-Retroviral AgentsFemaleHumansInfant, NewbornPregnancyAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral therapyPregnancyTeratogenicity

Identifiers

PMID38277098
PMCPMC11095844
OpenAlexW4391259722

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.