ArticleInternational journal of molecular sciences2024
Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic
Alena Welters, Oliver Nortmann, Laura Wörmeyer, Clemens Freiberg, Daniel Eberhard, Nadine Bachmann, Carsten Bergmann, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 2 institutions in 1 country.
Alena WeltersDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.ORCID 0000-0003-3951-4896 Oliver NortmannDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Laura WörmeyerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Clemens FreibergDepartment of Pediatrics and Adolescent Medicine, Pediatric Endocrinology, University Medicine Göttingen, D-37075 Göttingen, Germany.
Daniel EberhardInstitute of Metabolic Physiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Nadine BachmannMedizinische Genetik Mainz, Limbach Genetics, D-55128 Mainz, Germany.
Carsten BergmannMedizinische Genetik Mainz, Limbach Genetics, D-55128 Mainz, Germany.
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.ORCID 0000-0001-8460-3738 Thomas MeissnerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Sebastian KummerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Düsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DE
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The BiP co-chaperone DNAJC3 protects cells during ER stress. In mice, the deficiency of DNAJC3 leads to beta-cell apoptosis and the gradual onset of hyperglycemia. In humans, biallelic
Indexed as
Congenital HyperinsulinismHSP40 Heat-Shock ProteinsAdolescentAnimalsCalciumHumansInsulinInsulin SecretionMiceMolecular ChaperonesCalciumDNAJC3 protein, humanDnajc3 protein, mouseHSP40 Heat-Shock ProteinsInsulinMolecular ChaperonesBiP/GRP78 co-chaperonecalcium leakendoplasmic reticulum stresshyperinsulinemic hypoglycemiaintracellular calcium homeostasismonogenic diabetes
Identifiers
PMID38279270
PMCPMC10816850
OpenAlexW4391107042
What Socratic holds
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LicenceCC BY
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