ArticleParasites & vectors2024
Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding.
Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis.Insect molecular biology · 2026Article
- RmTIL, a cysteine-rich protein as a putative microbiota modulator from Rhipicephalus microplus tick.Parasitology research · 2026Article
- Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation.Communications biology · 2026Article
- Pepscan and bioinformatic strategies for identification of potential B-cell epitopes for a peptide-based vaccine for tick control.Molecular and biochemical parasitology · 2025Article
- IxsS7: A novel biomarker for Ixodes scapularis tick bite exposure in humans.Ticks and tick-borne diseases · 2025Article
- Multi-Omics Technologies Applied to Improve Tick Research.Microorganisms · 2025Review
- A deep insight into the sialome of the house fly, Musca domestica, infected with the salivary gland hypertrophy virus (MdSGHV).Scientific reports · 2025Article
- Depicting "arms race" of Rhipicephalus microplus and its host on a single frame platform.Parasitology research · 2025Article
- New Record of Rhipicephalus fulvus (Neumann, 1913) from Goats and Sheep in Northeastern Algeria After more than a Century.Acta parasitologica · 2025Article
- Serpins in the Spotlight: Novel Bioinformatic Insights IntoBiochemistry research international · 2025Article
- Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions.Current research in parasitology & vector-borne diseases · 2025Review
- Dissection and internal anatomy of the giant tropical bont tick Amblyomma variegatum.Parasite (Paris, France) · 2025Article
- Gut membrane proteins as candidate antigens for immunization of mice against the tick Amblyomma sculptum.Vaccine · 2024Article
- Tick exposure biomarkers: A One Health approach to new tick surveillance tools.Current research in parasitology & vector-borne diseases · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWhen feeding on a vertebrate host, ticks secrete saliva, which is a complex mixture of proteins, lipids, and other molecules. Tick saliva assists the vector in modulating host hemostasis, immunity, and tissue repair mechanisms. While helping the vector to feed, its saliva modifies the site where pathogens are inoculated and often facilitates the infection process. The objective of this study is to uncover the variation in protein composition of Rhipicephalus microplus saliva during blood feeding.
methodsTicks were fed on calves, and adult females were collected, weighed, and divided in nine weight groups, representing the slow and rapid feeding phases of blood feeding. Tick saliva was collected, and mass spectrometry analyses were used to identify differentially secreted proteins. Bioinformatic tools were employed to predict the structural and functional features of the salivary proteins. Reciprocal best hit analyses were used to identify conserved families of salivary proteins secreted by other tick species.
resultsChanges in the protein secretion profiles of R. microplus adult female saliva during the blood feeding were observed, characterizing the phenomenon known as "sialome switching." This observation validates the idea that the switch in protein expression may serve as a mechanism for evading host responses against tick feeding. Cattle tick saliva is predominantly rich in heme-binding proteins, secreted conserved proteins, lipocalins, and protease inhibitors, many of which are conserved and present in the saliva of other tick species. Additionally, another remarkable observation was the identification of host-derived proteins as a component of tick saliva.
conclusionsOverall, this study brings new insights to understanding the dynamics of the proteomic profile of tick saliva, which is an important component of tick feeding biology. The results presented here, along with the disclosed sequences, contribute to our understanding of tick feeding biology and might aid in the identification of new targets for the development of novel anti-tick methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.