ArticleFrontiers in neuroscience2024
Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus.
Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Bionic sleep therapy for refractory insomnia: a case report and literature review.BMC anesthesiology · 2026Review
- Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.Molecular brain · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- A Brainstem-Thalamic-Cortex Glutamatergic Neuron Pathway Modulates Propofol Anesthesia.Drug design, development and therapy · 2026Article
- Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep.British journal of anaesthesia · 2025Article
- Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.Nature computational science · 2025Article
- The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study.ACS chemical neuroscience · 2025Article
- Effects of propofol on the electrophysiological properties of glutamatergic neurons in the ventrolateral medulla of mice.BMC anesthesiology · 2024Article
- Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics.Frontiers in pharmacology · 2024Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals' locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
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