Evidence map›Paper›PMID 38285083›Full record

ReviewCurrent osteoporosis reports2024

Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health.

Sonali J Karnik, Tyler J Margetts, Hannah S Wang, Alexandru Movila, Adrian L Oblak, Jill C Fehrenbacher, Melissa A Kacena, Lilian I Plotkin

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Body Composition and Alzheimer's Disease: A Holistic Review.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonali J KarnikDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Tyler J MargettsDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Hannah S WangDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Alexandru MovilaDepartment of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN, 46202, USA.
Adrian L OblakDepartment of Radiology & Imaging Sciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jill C FehrenbacherIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Melissa A KacenaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkacena@iupui.edu.
Lilian I PlotkinIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. lplotkin@iupui.edu.

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - LOADR01AG060621 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KACENA, MELISSA A, LI, JILIANG · 2019 to 2023
$3.7M
Short-Term Training Program In Biomedical SciencesT35HL110854 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Brittney-Shea Herbert, Catherine Rufatto Sears · 2012 to 2026
$3.4M
Impact of Acid Ceramidase Activity on MIF-mediated migration of circulating osteoclast precursors to periodontal bone lesions in relation to agingR01AG064003 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2019 to 2022
$1.8M
Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down SyndromeK02AG068595 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2020 to 2024
$908k
Contribution of chromosome versus gonadal sex to bone mass and strengthR21AG078861 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2022 to 2023
$832k
Skeletal complications to a TREM2 variant associated with Alzheimer's DiseaseI01BX005154 · VA · RLR VA MEDICAL CENTER · PI PLOTKIN, LILIAN IRENE · 2021 to 2024
–
Impact of TPO Treatment on Bone Healing and Angiogenesis in Type 2 DiabetesI01BX003751 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2017 to 2021
–
"Novel therapeutic approaches to improve fracture healing while reducing pain behavior"I01RX003552 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2022 to 2025
–
RR&D Research Career Scientist Award ApplicationIK6RX004809 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2023 to 2025
–
BLRD VA I01 BX003751BLRD VA I01 BX005154BLRD VA I01 BX006399NCATS NIH HHS UL1 TR002529NHLBI NIH HHS T35 HL110854NIA NIH HHS K02 AG068595NIA NIH HHS R01 AG060621NIA NIH HHS R01 AG064003NIA NIH HHS R21 AG078861NIH HHS AG060621/AG060621-05S1/AG060621-05S2NIH HHS AG064003NIH HHS AG078861/AG078861-S1NIH HHS T35HL110854NIH HHS U54AG054345RRD VA I01 RX003552RRD VA IK6 RX004809
6 · The paper itself

Abstract

purpose of reviewThis review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in an aging population. RECENT

findingsAging intensifies both ADRD and bone deterioration. Notably, ADRD patients have a heightened fracture risk, impacting morbidity and mortality, though it is uncertain if fractures worsen ADRD. Therapeutically, agents targeting inflammation pathways, especially Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and TNF-α, appear beneficial for both conditions. Additionally, treatments like Sirtuin 1 (SIRT-1), known for anti-inflammatory and neuroprotective properties, are gaining attention. The interconnectedness of AD/ADRD and bone health necessitates a unified treatment approach. By addressing shared mechanisms, we can potentially transform therapeutic strategies, enriching our understanding and refining care in our aging society. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.

Indexed as

Alzheimer DiseaseDementiaAgedArtificial IntelligenceBone DensityHumansInflammationAIAlzheimer’s diseaseartificial intelligenceChatGPTEstrogenFractureInflammagingNeuroinflammationOsteoporosis

Identifiers

PMID38285083
PMCPMC10912190

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.