ArticleEnvironmental health perspectives2024
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.
Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026Review
- Analysis of 18 mercapturic acids in urine samples from the German Environmental Specimen Bank-tackling the data gap in the human biomonitoring of VOCs in Europe.Journal of exposure science & environmental epidemiology · 2026Article
- Early life phthalate and replacement plasticizer exposures and changes in early childhood brain functional connectivity and structural morphology.Environment international · 2026Article
- Closing the evidence loop-membrane-lipid homeostasis and vesicular transport link DEHP exposure to endometriosis.Human genomics · 2025Article
- Field cancerization, accelerated aging, and immunosuppression: the rapid rise of hormone-sensitive and early-onset breast cancer.NPJ breast cancer · 2025Review
- Environmental endocrine disruptors: rethinking the origins of early-onset ERNature reviews. Cancer · 2025Article
- Uncovering Exposure Patterns of Metals, PFAS, Phthalates, and PAHs and Their Combined Effect on Liver Injury Markers.Journal of xenobiotics · 2025Article
- Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort.Journal of exposure science & environmental epidemiology · 2025Article
- Review
- Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM).Environment international · 2025Article
- The Power of Strategic Social Media Influencer Communication to Improve Black Women's Knowledge and Awareness of Environmental Endocrine-Disrupting Chemicals: Surveys of Instagram Users.Journal of medical Internet research · 2025Article
- Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model.Environmental health perspectives · 2025Article
- Aggregate index of systemic inflammation tied to increased fatty liver disease risk: insights from NHANES data.BMC gastroenterology · 2025Article
- Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Health impacts of exposure to synthetic chemicals in food.Nature medicine · 2025Review
- Environmental basis for early onset breast cancer.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring studies provide insight into how chemical exposures change over time.
objectivesWe constructed an exposure landscape for as many human-exposure relevant chemicals over as large a time span as possible to characterize exposure trends across demographic groups and chemical types.
methodsWe analyzed urine data of nine 2-y cohorts (1999-2016) from the National Health and Nutrition Examination Survey (NHANES). Chemical daily intake rates (in milligrams per kilogram bodyweight per day) were inferred, using the R package bayesmarker, from metabolite concentrations in each cohort individually to identify exposure trends. Trends for metabolites and parents were clustered to find chemicals with similar exposure patterns. Exposure variation by age, gender, and body mass index were also assessed.
resultsIntake rates for 179 parent chemicals were inferred from 151 metabolites (96 measured in five or more cohorts). Seventeen metabolites and 44 parent chemicals exhibited fold-changes DISCUSSION: With appropriate analysis, NHANES indicates trends in chemical exposures over the past two decades. Decreases in exposure are observable as the result of regulatory action, with some being accompanied by increases in replacement chemicals. Age- and gender-specific variations in exposure were observed for multiple chemicals. Continued estimation of demographic-specific exposures is needed to both monitor and identify potential vulnerable populations. https://doi.org/10.1289/EHP12188.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.