SynthesisClinical and experimental medicine2024
The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis.
Synthesis in Clinical and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A systematic review and meta-analysis of the systemic immune-inflammation index (SII) in rheumatic diseases.Frontiers in immunology · 2026Pooled it
- Comparative Value of Traditional versus Novel Immune-Inflammatory Indices in Assessing Disease Activity of Sjögren's Disease: A Multicenter Cohort Study.Clinical rheumatology · 2026Article
- Endoscopic Activity Prediction in Ulcerative Colitis Using Hemogram-Derived Inflammatory Indices: Impact of Azathioprine Use on Diagnostic Performance.Journal of clinical medicine · 2026Article
- Associations of Systemic Immune-Inflammation Index and Hematological Markers with Symptom Burden and Radiological Stage in Sarcoidosis.Diagnostics (Basel, Switzerland) · 2026Article
- From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices.npj aging · 2026Article
- Longitudinal biomarker trajectories accompanying trichoscopic change after PRP-based regimens for alopecia: a complementary multi-marker analysis of a real-world cohort.Journal of medicine and life · 2026Article
- Associations of systemic immune-inflammation index and aggregate index of systemic inflammation with acute gouty arthritis in men: a cross-sectional study.Frontiers in medicine · 2026Article
- FT3 Levels and Systemic Inflammation: Evidence From a Population-Based NHANES Analysis.Mediators of inflammation · 2026Article
- Association of Baseline Systemic Immune-Inflammation Index With Severe Sleep Disturbance in Patients With Neuropathic Pain: A Prospective Longitudinal Observational Cohort Study.Pain research & management · 2026Observational
- A novel composite inflammatory-metabolic index for long-term prognosis after TAVR: the modifying role of left ventricular ejection fraction.Frontiers in cardiovascular medicine · 2026Article
- Early systemic immune-inflammation index is associated with mortality and functional outcome in brainstem hemorrhage.Frontiers in neurology · 2026Article
- Perioperative predictors of delayed recovery after pancreatic and biliary surgeries: The role of hematologic indices.SAGE open medicine · 2026Article
- Systemic Immune-Inflammation Index as a Marker of Activity in Behcet's Uveitis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study.Frontiers in endocrinology · 2026Observational
- Pan-Immune Inflammation Value as a Novel Comprehensive Predictor of In-Hospital Mortality in Patients with Severe Burns: A Single-Center Retrospective Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Systemic Inflammation Indices, Chemokines, and Metabolic Markers in Perimenopausal Women.Nutrients · 2025Article
- Exploring the Link Between Inflammatory Biomarkers (SII, SIRI, PLR, NLR, LMR) and Migraine in Young and Early Middle-Aged US Adults: Evidence From NHANES 1999-2004 and Machine Learning Models.Brain and behavior · 2025Article
- Evaluation of Systemic Inflammatory Indices of Earthquake Victims After the 6 February Kahramanmaraş Earthquake.Thoracic research and practice · 2025Article
- Predictive factors in difficult postoperative airway management of severe odontogenic deep neck infection.Odontology · 2025Article
- The Role of Preoperative Immunonutritional Scores in Predicting Complications After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of novel, easily measurable biomarkers of inflammation might enhance the diagnosis and management of immunological diseases (IDs). We conducted a systematic review and meta-analysis to investigate an emerging biomarker derived from the full blood count, the systemic inflammation index (SII), in patients with IDs and healthy controls. We searched Scopus, PubMed, and Web of Science from inception to 12 December 2023 for relevant articles and evaluated the risk of bias and the certainty of evidence using the Joanna Briggs Checklist and the Grades of Recommendation, Assessment, Development, and Evaluation Working Group system, respectively. In 16 eligible studies, patients with IDs had a significantly higher SII when compared to controls (standard mean difference, SMD = 1.08, 95% CI 0.75 to 1.41, p < 0.001; I
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.