Evidence map›Paper›PMID 38287012›Full record

ArticleNature communications2024

CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.

Marc Scherlinger, Hao Li, Wenliang Pan, Wei Li, Kohei Karino, Theodoros Vichos, Afroditi Boulougoura, Nobuya Yoshida, Maria G Tsokos, George C Tsokos

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  4. Integrative Transcriptomic and Proteomic Analysis RevealsAnimals : an open access journal from MDPI · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Marc ScherlingerDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. marc.scherlinger@chru-strasbourg.fr.ORCID 0000-0002-9453-5895
Hao LiDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-2171-8826
Wenliang PanDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Wei LiDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kohei KarinoDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-5319-3174
Theodoros VichosDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0009-0002-7237-1954
Afroditi BoulougouraDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nobuya YoshidaDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Maria G TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-8072-1358
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. gtsokos@bidmc.harvard.edu.ORCID 0000-0001-9589-2360
Beth Israel Deaconess Medical Center · US

Funding

Gene transcription in SLER37AI049954 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSOKOS, GEORGE C · 2013 to 2022
$4.8M
NIAID NIH HHS R37 AI049954
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell compartment responsible for the production of autoantibodies. Here, we show that T cell-specific expression of calcium/calmodulin-dependent protein kinase IV (CaMK4) leads to T follicular helper (T

Indexed as

Lupus Erythematosus, SystemicT Follicular Helper CellsAnimalsAutoimmunityCalcium-Calmodulin-Dependent Protein Kinase Type 4Cell DifferentiationHumansImmunoglobulin GMiceT-Lymphocytes, Helper-InducerCalcium-Calmodulin-Dependent Protein Kinase Type 4CAMK4 protein, humanCamk4 protein, mouseImmunoglobulin G

Identifiers

PMID38287012
PMCPMC10825135
OpenAlexW4391318846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.