Evidence map›Paper›PMID 38287041›Full record

ArticleScientific reports2024

A home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells.

Giulia Baldelli, Valentina Natalucci, Carlo Ferri Marini, Davide Sisti, Giosuè Annibalini, Roberta Saltarelli, Matteo Bocconcelli, Veronica Gentilini, Rita Emili, Marco Bruno Luigi Rocchi and 4 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giulia Baldelli *Unit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Valentina Natalucci *Division of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Carlo Ferri MariniDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Davide SistiUnit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy. davide.sisti@uniurb.it.
Giosuè AnnibaliniDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy. giosue.annibalini@uniurb.it.
Roberta SaltarelliDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Matteo BocconcelliDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Veronica GentiliniUnit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Rita EmiliMedical Oncology, Hospital Santa Maria della Misericordia di Urbino, 61029, Urbino, Italy.
Marco Bruno Luigi RocchiUnit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Francesco LucertiniDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Elena BarbieriDivision of Exercise and Health Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Giorgio BrandiUnit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Mauro De SantiUnit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translational research for the evaluation of physical activity habits and lifestyle modifications based on nutrition and exercise has recently gained attention. In this study, we evaluated the effects of serum samples obtained before and after a 12-week home-based lifestyle intervention based on nutrition and exercise in breast cancer survivors in terms of modulation of the tumorigenic potential of breast cancer cells. The home-based lifestyle intervention proposed in this work consisted of educational counselling on exercise and nutritional behaviors and in 12 weeks of structured home-based exercise. Triple-negative breast cancer cell line MDA-MB-231 was cultured in semi-solid medium (3D culture) with sera collected before (PRE) and after (POST) the lifestyle intervention program. Spheroid formation was evaluated by counting cell colonies after 3 weeks of incubation. Results show a slight but significant reduction of spheroid formation induced by serum collected POST in comparison to those obtained PRE. Moreover, statistical analyses aimed to find physiologic and metabolic parameters associated with 3D cell proliferation revealed the proliferative inducer IGF-1 as the only predictor of cell tumorigenic potential. These results highlight the importance of lifestyle changes for cancer progression control in a tertiary prevention context. Translational research could offer a useful tool to identify metabolic and physiological changes induced by exercise and nutritional behaviors associated with cancer progression and recurrence risk.

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsCarcinogenesisCounselingExerciseFemaleHealth BehaviorHumansLife Style

Identifiers

PMID38287041
PMCPMC10824728

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.