ArticleThe American journal of physiology1979
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
Article in The American journal of physiology, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 17 registered trials, which are not on this map. Cited by 2,425 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.
Effect of a Quadruple Therapy on Pancreatic Islet Function, Insulin Resistance and Cardiovascular Function in Patients With Mixed Prediabetes and Obesity: Randomized Clinical Trial
Beta Cell Function in (Pre) Type 1 Diabetes
Effect of DMMET-01 on Insulin Sensitivity in Naive Type 2 Diabetes Patients by Glucose CLAMP Technique
Metabolic Effects of Testosterone Alone or in Combination With Dutasteride or Anastrazole in Obese Men
Very Low Calorie Diet: a Quick Therapeutic Tool to Improve Beta Cell Function in Morbidly Obese Patients With Type 2 Diabetes Mellitus
The Effects of Bariatric Surgeries on Non-Alcoholic Fatty Liver Disease
Evaluation of the Effect of Different Foods, Carbohydrate Meal, and a Euglycaemic Insulin Clamp on the QT/QTc Interval Using a Single Dose of Moxifloxacin as a Positive Control in Healthy Male and Female, Caucasian and Japanese Volunteers
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain
Effects of Chronic Dietary Exposure to Branched Chain Amino Acids on Insulin Sensitivity Measures in Healthy Vegans and Omnivores
Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity
Acute Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus
Effect of Resistant Starch From Green Banana Flour on the Insulin Sensitivity of Subjects With Prediabetes: Randomized Clinical Trial
Determination of the Time-course of Development of Insulin Resistance, and Associated Molecular and Muscular Adaptations, During Inactivity in 3 Days of Bed-rest
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment
A Randomized, Double-Blind, Cross Over Study to Assess Pharmacokinetic and Pharmacodynamic Effects of Insulex® R in Comparison to Humulin® R in Healthy Subjects
Who cites it
2,425 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Relationship between aerobic fitness and adipose tissue insulin resistance.American journal of physiology. Endocrinology and metabolism · 2026Pooled it
- The association between triglyceride-glucose index and polycystic ovary syndrome: a systematic review and meta-analysis across different populations.Journal of ovarian research · 2025Pooled it
- The role of estimated glucose disposal rate in predicting cardiovascular risk among general and diabetes mellitus population: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Trial
- Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial.The Journal of clinical endocrinology and metabolism · 2026Trial
- Insulin Sensitivity and Beta Cell Function With Macupatide Alone or With Dulaglutide in Type 2 Diabetes: A Phase 1b, Randomised Controlled Trial.Diabetes, obesity & metabolism · 2026Trial
- Lipid Challenge Reveals Amplified Apolipoprotein Responses with Preserved Temporal Pattern in Polyendocrine Metabolic Ovarian Syndrome: An Exploratory Study.International journal of molecular sciences · 2026Trial
- Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals.American journal of physiology. Endocrinology and metabolism · 2026Trial
- Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial.Nature communications · 2026Trial
- Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome.Diabetes, obesity & metabolism · 2026Trial
- Population Pharmacokinetic and Pharmacodynamic Modeling to Support Molar Dose Ratio Determination of Long-Acting Insulin Analogs.Clinical pharmacokinetics · 2026Trial
- Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus.Cardiovascular diabetology · 2025Trial
- Early induction of insulin sensitisation treated by tirzepatide: a prospective, single-arm, open-label study in Japanese individuals with obesity and type 2 diabetes.Diabetologia · 2025Trial
- Effects of reducing sedentary behaviour on renal glucose uptake during insulin stimulation: A post-hoc analysis of a 6-month randomized controlled trial.Diabetes, obesity & metabolism · 2025Trial
- Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity.Cell reports. Medicine · 2025Trial
- Optimizing measures of insulin-regulated lipolysis in humans.American journal of physiology. Endocrinology and metabolism · 2025Trial
- Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Trial
- Article
- Sex-specific association between metabolic score for insulin resistance and mortality in incident peritoneal dialysis patients.Renal failure · 2026Article
2,365 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. Hyperglycemic clamp technique. The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a priming infusion of glucose. The desired hyperglycemic plateau is subsequently maintained by adjustment of a variable glucose infusion, based on the negative feedback principle. Because the plasma glucose concentration is held constant, the glucose infusion rate is an index of glucose metabolism. Under these conditions of constant hyperglycemia, the plasma insulin response is biphasic with an early burst of insulin release during the first 6 min followed by a gradually progressive increase in plasma insulin concentration. Euglycemic insulin clamp technique. The plasma insulin concentration is acutely raised and maintained at approximately 100 muU/ml by a prime-continuous infusion of insulin. The plasma glucose concentration is held constant at basal levels by a variable glucose infusion using the negative feedback principle. Under these steady-state conditions of euglycemia, the glucose infusion rate equals glucose uptake by all the tissues in the body and is therefore a measure of tissue sensitivity to exogenous insulin.
Indexed as
Identifiers
382871What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.