Evidence map›Paper›PMID 38287458›Full record

ArticleEuropean journal of medical research2024

Exploring clinical indicator variations in stroke patients with multiple risk factors: focus on hypertension and inflammatory reactions.

Jiejie Guo, Mei Tian, Yongang Li, Yitong Guo, Ting Zhang, Xuan Liu, Jinze Shen, Lin Zhang, Yueqi Yu, Ling Cao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jiejie Guo *Zhejiang Key Laboratory of Pathophysiology, NBU Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.
Mei Tian *College of Pharmacy, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China.
Yongang LiDepartment of Neurology, The Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Yitong GuoKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Ting ZhangDepartment of Clinical Laboratory, The Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Xuan LiuDepartment of Neurology, The Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Jinze ShenKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Lin ZhangDepartment of Neurology, The Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, 317500, Zhejiang, China.
Yueqi YuKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Ling CaoNingbo Rehabilitation Hospital, Ningbo, 315040, China.
Haiyan GuNingbo Rehabilitation Hospital, Ningbo, 315040, China.
Yanfang LiNingbo Rehabilitation Hospital, Ningbo, 315040, China.
Shiwei DuanKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China. duansw@hzcu.edu.cn.
Qinwen WangZhejiang Key Laboratory of Pathophysiology, NBU Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China. wangqinwen@nbu.edu.cn.
Wenzhou Medical University · CNHangzhou City UniversityNingbo University · CNZhejiang University of Technology · CN

Funding

Science Foundation of Jiangdong 2015C50037Science Foundation of Yinzhou 2019AS0037Taizhou Science and Technology Project No.20ywb135Taizhou Science and Technology Project No.21ywb123the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2019KY202the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission No.2019RC316the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission No.2021KY1228The Natural Science Foundation of Zhejiang Province No. LQ19H090001Wenling Science and Technology Project No.2020S0180128Wenling Science and Technology Project No.2021S00158
6 · The paper itself

Abstract

backgroundStroke stands as the second leading cause of death worldwide. Currently, extensive research has been conducted on stroke risk factors. However, when stroke patients contend with multiple risk factors, the impact on clinical indicators remains uncertain.

objectivesThis study seeks to investigate potential significant variations among distinct ranges of clinical indicators in instances where stroke patients experience multiple risk factors and various ischemic stroke subtypes. MATERIAL AND

methodsThe research encompassed 440 stroke patients admitted to the First People's Hospital of Wenling City, Zhejiang Province, China. These patients were classified based on the type and quantity of risk factors and subtypes of ischemic stroke they presented. The χ

resultsThe results of our study have underscored a significant correlation between various comorbid risk factors in stroke patients and the patients' age (P < 0.010). Furthermore, we observed noteworthy disparities in the plasma levels of IL-2, IL-4, IL-6, IL-10, TNF-α, and INF-γ between patients devoid of risk factors and those presenting with comorbid risk factors associated with stroke. Significant differences in INF-γ were observed between the two subtypes of ischemic stroke, namely lacunar infarction and cardioembolic stroke.

conclusionAge is correlated with an elevated risk of stroke. Individuals exhibiting multiple stroke risk factors and diverse ischemic stroke subtypes commonly present with abnormal lipid levels and imbalances in Th1/Th2 cytokines. These factors significantly contribute to the onset and progression of stroke. Furthermore, inflammatory responses, particularly those induced by atherosclerosis, play a pivotal role in the genesis of stroke and exert a substantial influence on its prognosis.

Indexed as

HypertensionIschemic StrokeStrokeHumansInflammationRisk FactorsClinical indicatorsInflammatory reactionsIschemic stroke subtypeRisk factorsStroke

Identifiers

PMID38287458
PMCPMC10823715
OpenAlexW4391316940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.