Evidence map›Paper›PMID 38287520›Full record

ArticleCNS neuroscience & therapeutics2024

rTMS reduces delta and increases theta oscillations in Alzheimer's disease: A visual-evoked and event-related potentials study.

Halil Aziz Velioglu, Esra Zeynep Dudukcu, Lutfu Hanoglu, Bahar Guntekin, Tuba Akturk, Burak Yulug

Open access · goldAbstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Halil Aziz VeliogluCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York, USA.ORCID 0000-0002-2306-5937
Esra Zeynep DudukcuFunctional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN), Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey.
Lutfu HanogluDepartment of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Bahar GuntekinDepartment of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Tuba AkturkProgram of Electroneurophysiology, Vocational School, Istanbul Medipol University, Istanbul, Turkey.
Burak YulugDepartment of Neurology and Clinical Neuroscience, School of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.ORCID 0000-0002-6173-9074
Istanbul Medipol University · TRAlanya University · TRFeinstein Institute for Medical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRepetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for Alzheimer's disease (AD) due to its ability to modulate neural networks and enhance cognitive function. This treatment offers the unique advantage of enabling real-time monitoring of immediate cognitive effects and dynamic brain changes through electroencephalography (EEG).

objectiveThis study focused on exploring the effects of left parietal rTMS stimulation on visual-evoked potentials (VEP) and visual event-related potentials (VERP) in AD patients.

methodsSixteen AD patients were recruited for this longitudinal study. EEG data were collected within a Faraday cage both pre- and post-rTMS to evaluate its impact on potentials.

resultsSignificant alterations were found in both VEP and VERP oscillations. Specifically, delta power in VEP decreased, while theta power in VERP increased post-rTMS, indicating a modulation of brain activities. DISCUSSION: These findings confirm the positive modulatory impact of rTMS on brain activities in AD, evidenced by improved cognitive scores. They align with previous studies highlighting the potential of rTMS in managing hyperexcitability and oscillatory disturbances in the AD cortex.

conclusionCognitive improvements post-rTMS endorse its potential as a promising neuromodulatory treatment for cognitive enhancement in AD, thereby providing critical insights into the neurophysiological anomalies in AD and possible therapeutic avenues.

Indexed as

Alzheimer DiseaseTranscranial Magnetic StimulationElectroencephalographyEvoked PotentialsHumansLongitudinal StudiesADrTMSVEPVERP

Identifiers

PMID38287520
PMCPMC10805393
OpenAlexW4390842072

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.