Evidence map›Paper›PMID 38287718›Full record

ArticleDiabetes/metabolism research and reviews2024

Type 2 diabetes metabolomics score and risk of progression to type 2 diabetes among women with a history of gestational diabetes mellitus.

Deirdre K Tobias, Rikuta Hamaya, Clary B Clish, Liming Liang, Amy Deik, Courtney Dennis, Kevin Bullock, Cuilin Zhang, Frank B Hu, JoAnn E Manson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes/metabolism research and reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Illuminating diabetesWorld journal of diabetes · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deirdre K TobiasDivision of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-0020-9552
Rikuta HamayaDivision of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Liming LiangBiostatistics Department, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Amy DeikBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Courtney DennisBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kevin BullockBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Cuilin ZhangEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Frank B HuNutrition Department, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
Metabolomics and type 2 diabetes risk among high-risk women with a history of gestational diabetesK01DK103720 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI TOBIAS, DEIRDRE KAY · 2014 to 2016
$396k
NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA176726NIDDK NIH HHS K01 DK103720NIDDK NIH HHS K01DK103720NIDDK NIH HHS P30 DK040561NIH HHS R01 CA67262NIH HHS U01 CA176726
6 · The paper itself

Abstract

backgroundSeveral metabolites are individually related to incident type 2 diabetes (T2D) risk. We prospectively evaluated a novel T2D-metabolite pattern with a risk of progression to T2D among high-risk women with a history of gestational diabetes mellitus (GDM).

methodsThe longitudinal Nurses' Health Study II cohort enroled 116,429 women in 1989 and collected blood samples from 1996 to 1999. We profiled plasma metabolites in 175 incident T2D cases and 175 age-matched controls, all with a history of GDM before the blood draw. We derived a metabolomics score from 21 metabolites previously associated with incident T2D in the published literature by scoring according to the participants' quintile (1-5 points) of each metabolite. We modelled the T2D metabolomics score categorically in quartiles and continuously per 1 standard deviation (SD) with the risk of incident T2D using conditional logistic regression models adjusting for body mass index at the blood draw, and other established T2D risk factors.

resultsThe percentage of women progressing to T2D ranged from 10% in the bottom T2D metabolomics score quartile to 78% in the highest score quartile. Adjusting for established T2D risk factors, women in the highest quartile had more than a 20-fold greater diabetes risk than women in the lowest quartile (odds ratios [OR] = 23.1 [95% CI = 8.6, 62.1]; p for trend<0.001). The continuous T2D metabolomics score was strongly and positively associated with incident T2D (adjusted OR = 2.7 per SD [95% CI = 1.9, 3.7], p < 0.0001).

conclusionsA pattern of plasma metabolites among high-risk women is associated with a markedly elevated risk of progression to T2D later in life.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2FemaleHumansMetabolomicsOdds RatioPregnancyRisk Factorsgestational diabetesmetabolomicsmetabolomics scoreprospective cohorttype 2 diabetes

Identifiers

PMID38287718
PMCPMC10842268

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.