ArticleFrontiers in neurology2023
Altered dynamic effective connectivity of the default mode network in type 2 diabetes.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus.Frontiers in neuroscience · 2026Article
- Investigating the impact of type 2 diabetes mellitus on brain function in obstructive sleep apnea patients using regional homogeneity and seed-based functional connectivity methods.Frontiers in neuroscience · 2025Article
- Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.Scientific reports · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Altered functional connectivity of resting-state functional magnetic resonance imaging (rs-fMRI) within default mode network (DMN) regions has been verified to be closely associated with cognitive decline in patients with Type 2 diabetes mellitus (T2DM), but most studies neglected the fluctuations of brain activities-the dynamic effective connectivity (DEC) within DMN of T2DM is still unknown. Methods: For the current investigation, 40 healthy controls (HC) and 36 T2DM patients have been recruited as participants. To examine the variation of DEC between T2DM and HC, we utilized the methodologies of independent components analysis (ICA) and multivariate granger causality analysis (mGCA). Results: We found altered DEC within DMN only show decrease in state 1. In addition, the causal information flow of diabetic patients major affected areas which are closely associated with food craving and metabolic regulation, and T2DM patients stayed longer in low activity level and exhibited decreased transition rate between states. Moreover, these changes related negatively with the MoCA scores and positively with HbA1C level. Conclusion: Our study may offer a fresh perspective on brain dynamic activities to understand the mechanisms underlying T2DM-related cognitive deficits.
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