ArticleScience signaling2024
Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.
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Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Sex Differences and Oxidative Stress in Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- Pannexins in the heart: cell-specific expression and contributions to disease.Cell and tissue research · 2026Review
- Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease.Comprehensive Physiology · 2025Review
- Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025Review
- Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025Review
- Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Ethyl Acetate Extract ofMetabolites · 2025Article
- Pannexin channels in inflammation and tumorigenesis.Frontiers in cell and developmental biology · 2025Review
- Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury.Infection and drug resistance · 2025Review
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 2 countries.
Abigail G WolpeRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-4169-3697
Melissa A LuseRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-5425-4717
Christopher BaryiamesDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0001-5683-8126
Wyatt J SchugRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jacob B WolpeDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Scott R JohnstoneFralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Center for Vascular and Heart Research, Roanoke, VA 24016, USA.ORCID 0000-0003-1920-5033
Luke S DunawayRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-7458-9669
Zuzanna J JuśkiewiczRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0009-0006-2612-2665
Skylar A LoebRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0003-0213-5163
Henry R Askew PageRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-8521-6828
Yen-Lin ChenRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0003-1149-394X
Vikram SabapathyCenter for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-7319-0998
Caitlin M PavelecDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Brent WakefieldDepartment of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0003-4760-9967
Eugenia Cifuentes-PaganoHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2482-080X
Mykhaylo V ArtamonovDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-0848-2054
Avril V SomlyoRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-9997-4897
Adam C StraubHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Rahul SharmaCenter for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-3115-3523
Frank BeierDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-8505-7537
Eugene J BarrettDepartment of Medicine, Division of Endocrinology and Metabolism, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Norbert LeitingerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-6224-5175
Patrick J PaganoHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-7475-808X
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-9587-9342
Stefanie RedemannDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0003-2334-7309
Linda ColumbusDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0002-2574-0561
Silvia PenuelaDepartment of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0003-4829-5517
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-7692-6294
University of Virginia · USUniversity of Pittsburgh · USWestern University · CACenter for Neuroscience and Regenerative Medicine · USCarilion Clinic · US
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A. · 2014 to 2023
$24.0MBASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MBasic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7MPurinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7MParacrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4MNew Signaling Networks in Vascular Smooth MuscleR01HL147555 · NHLBI · UNIVERSITY OF VIRGINIA · PI DEREWENDA, ZYGMUNT S, SOMLYO, AVRIL V. · 2020 to 2024
$3.6MBiophysical understanding of pathogen-host membrane protein interactions for drug discovery and deliveryR35GM131829 · NIGMS · UNIVERSITY OF VIRGINIA · PI Linda M Columbus · 2019 to 2026
$3.2MThe role of microtubule dynamics in midzone driven chromosome segregation in anaphaseR01GM144668 · NIGMS · UNIVERSITY OF VIRGINIA · PI Stefanie Redemann · 2022 to 2026
$2.0MPannexin 3 channels in endothelial-derived vasodilationF31HL149221 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANTOINE, ABIGAIL · 2019 to 2020
$67kNHLBI NIH HHS F31 HL149221NHLBI NIH HHS P01 HL120840NHLBI NIH HHS R01 HL137112NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R01 HL147555NHLBI NIH HHS R35 HL161177NHLBI NIH HHS T32 HL007284NIGMS NIH HHS R01 GM144668NIGMS NIH HHS R35 GM131829
Abstract
Targeted degradation regulates the activity of the transcriptional repressor Bcl6 and its ability to suppress oxidative stress and inflammation. Here, we report that abundance of endothelial Bcl6 is determined by its interaction with Golgi-localized pannexin 3 (Panx3) and that Bcl6 transcriptional activity protects against vascular oxidative stress. Consistent with data from obese, hypertensive humans, mice with an endothelial cell-specific deficiency in
Indexed as
HypertensionTranscription FactorsAnimalsCell DifferentiationCell ProliferationConnexinsHumansHydrogen PeroxideMiceObesityOxidative StressProto-Oncogene Proteins c-bcl-6Bcl6 protein, mouseConnexinsHydrogen Peroxidepannexin 3 protein, mouseProto-Oncogene Proteins c-bcl-6Transcription Factors
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.