Evidence map›Paper›PMID 38292613›Full record

ArticleACS central science2024

Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells.

Thomas G Bartholow, Paul W W Burroughs, Susanna K Elledge, James R Byrnes, Lisa L Kirkemo, Virginia Garda, Kevin K Leung, James A Wells

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. AbioRxiv : the preprint server for biology · 2026
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  15. Review
  16. Article
  17. Cancers · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thomas G BartholowDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Paul W W BurroughsDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Susanna K ElledgeDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
James R ByrnesDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Lisa L KirkemoDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Virginia GardaDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Kevin K LeungDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-2087-4974
James A WellsDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0001-8267-5519
University of California, San Francisco · US

Funding

Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolutionR35GM122451 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAMES A WELLS · 2017 to 2026
$5.3M
Research Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1M
New protein engineering-based tools and technologies for characterizing cell surface proteolysis in cancer cells for novel neo-epitope biomarkers and drug targetsR01CA248323 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAMES A WELLS · 2020 to 2026
$2.6M
NCI NIH HHS R01 CA248323NIGMS NIH HHS R35 GM122451NIGMS NIH HHS T32 GM145460
6 · The paper itself

Abstract

The cell surface proteome (surfaceome) plays a pivotal role in virtually all extracellular biology, and yet we are only beginning to understand the protein complexes formed in this crowded environment. Recently, a high-resolution approach (μMap) was described that utilizes multiple iridium-photocatalysts attached to a secondary antibody, directed to a primary antibody of a protein of interest, to identify proximal neighbors by light-activated conversion of a biotin-diazirine to a highly reactive carbene followed by LC/MS (Geri, J. B.; Oakley, J. V.; Reyes-Robles, T.; Wang, T.; McCarver, S. J.; White, C. H.; Rodriguez-Rivera, F. P.; Parker, D. L.; Hett, E. C.; Fadeyi, O. O.; Oslund, R. C.; MacMillan, D. W. C.

Identifiers

PMID38292613
PMCPMC10823516
OpenAlexW4390268872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.