Evidence map›Paper›PMID 38293019›Full record

ArticlebioRxiv : the preprint server for biology2024

Heat Shock Proteins Function as Signaling Molecules to Mediate Neuron-Glia Communication During Aging.

Jieyu Wu, Olivia Jiaming Yang, Erik J Soderblom, Dong Yan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jieyu WuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-3638-9313
Olivia Jiaming YangDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Erik J SoderblomProteomics and Metabolomics Core Facility, Duke University Medical School, Durham, NC 27710, USA.
Dong YanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-7542-1251

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Use of C. elegans as a model to study aging-associated neurodegenerationR01AG073994 · NIA · DUKE UNIVERSITY · PI Dong Yan · 2022 to 2026
$2.5M
Genetic study of gap junction formation and regulation in C. elegans neuronsR01NS105638 · NINDS · DUKE UNIVERSITY · PI YAN, DONG · 2018 to 2022
$1.8M
Use of C. elegans as a model to study aging-associated neurodegenerationR56AG073994 · NIA · DUKE UNIVERSITY · PI YAN, DONG · 2021 to 2021
$511k
NIA NIH HHS R01 AG073994NIA NIH HHS R56 AG073994NIH HHS P40 OD010440NINDS NIH HHS R01 NS105638
6 · The paper itself

Abstract

The nervous system is primarily composed of neurons and glia, and the communication between them plays profound roles in regulating the development and function of the brain. Neuron-glia signal transduction is known to be mediated by secreted or juxtacrine signals through ligand-receptor interactions on the cell membrane. Here, we report a novel mechanism for neuron-glia signal transduction, wherein neurons transmit proteins to glia through extracellular vesicles, activating glial signaling pathways. We find that in the amphid sensory organ of

Indexed as

agingC. eleganschondroitinextracellular vesiclesgliaheat shock proteinsneuronUPRER

Identifiers

PMID38293019
PMCPMC10827141

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.