Evidence map›Paper›PMID 38293075›Full record

ArticlebioRxiv : the preprint server for biology2024

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Alberto Granzotto, Amanda McQuade, Jean Paul Chadarevian, Hayk Davtyan, Stefano L Sensi, Ian Parker, Mathew Blurton-Jones, Ian Smith

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alberto GranzottoUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States.ORCID 0000-0001-9181-4373
Amanda McQuadeUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States.
Jean Paul ChadarevianUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States.
Hayk DavtyanUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States.
Stefano L SensiCenter for Advanced Sciences and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.ORCID 0000-0002-0710-2574
Ian ParkerDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.
Mathew Blurton-JonesUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States.
Ian SmithDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, United States.

Funding

Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI JUNMIN PENG · 2021 to 2026
$42.0M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
ENGINEERED HUMAN MICROGLIA AS A CELL-BASED THERAPY FOR A-BETA PLAQUE REMOVALR21AG073787 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2021 to 2022
$424k
NIA NIH HHS P30 AG066519NIA NIH HHS R21 AG073787NIA NIH HHS T32 AG073088NIA NIH HHS U19 AG069701
6 · The paper itself

Abstract

The central nervous system (CNS) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal cord. Alterations in the homeostasis of the CNS are detected by microglia that respond by migrating toward the affected area. Understanding the mechanisms controlling directed cell migration of microglia is crucial to dissect their responses to neuroinflammation and injury. We used a combination of pharmacological and genetic approaches to explore the involvement of calcium (Ca

Identifiers

PMID38293075
PMCPMC10827168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.