Evidence map›Paper›PMID 38297007›Full record

ArticleScientific reports2024

Craniofacial and olfactory sensory changes after long-term unilateral nasal obstruction-an animal study using MMP-3-LUC transgenic rats.

Li-Fang Hsu, Nutthakarn Ratanasereeprasert, Shih-Kai Wang, Jung-Tsu Chen, Yi-Jane Chen, Te-Huei Yeh, Hsiang-Hsuan Sung, Chung-Chen Jane Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Li-Fang HsuDepartment of Dentistry, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.
Nutthakarn RatanasereeprasertGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, No. 1, Chang-Te Street, Taipei, 10048, Taiwan.
Shih-Kai WangDepartment of Dentistry, National Taiwan University School of Dentistry, Taipei, Taiwan.
Jung-Tsu ChenGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, No. 1, Chang-Te Street, Taipei, 10048, Taiwan.
Yi-Jane ChenDepartment of Dentistry, National Taiwan University School of Dentistry, Taipei, Taiwan.
Te-Huei YehDepartment of Otolaryngology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsiang-Hsuan SungNational Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan.
Chung-Chen Jane YaoGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, No. 1, Chang-Te Street, Taipei, 10048, Taiwan. janeyao@ntu.edu.tw.
National Taiwan University Hospital · TWNational Taiwan University · TWNational Institutes of Applied Research · TW

Funding

Ministry of Science and Technology, Taiwan 111-2314-B-002-112National Taiwan University Hospital Hsinchu Branch 111-HCH006
6 · The paper itself

Abstract

Nasal obstruction exerts considerable physiological effects on the respiratory system and craniofacial morphology during the developmental stage. This study used MMP-3-LUC transgenic rats for in vivo tracking of long-term expression in the rat nasal region after unilateral nasal obstruction. Skeletal changes of the craniofacial, nasal, and sinus regions were measured through micro-computed tomography examination and analysis with 3D image processing and calculation. Matrix metalloproteinase-3 and olfactory marker protein expression were also investigated through immunohistochemistry (IHC). Unilateral nasal obstruction significantly reduced the MMP-3 signal in the nasal region of MMP-3-LUC transgenic rats, which was mainly expressed in the respiratory epithelium. Long-term obstruction also caused morphological changes of the craniofacial hard tissue, such as nasal septal deviation, longer inter-jaw distance, and increased maxillary molar dental height. It also caused compensatory growth in olfactory nerve bundles and the olfactory epithelium, as confirmed by IHC. In our study, long-term unilateral nasal obstruction caused nasal septal deviation toward the unobstructed side, hyper divergent facial development including longer molar dental height, and reduced MMP-3 production. However, further investigation is necessary to explore the mechanism in depth.

Indexed as

Nasal ObstructionAnimalsAnimals, LaboratoryMatrix Metalloproteinase 3Nasal SeptumRatsRats, TransgenicX-Ray MicrotomographyMatrix Metalloproteinase 3

Identifiers

PMID38297007
PMCPMC10830476
OpenAlexW4391383074

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.