ArticleNature2024
An epigenetic barrier sets the timing of human neuronal maturation.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
74.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 190 citations in OpenAlex.
- Direct neuronal reprogramming: emerging therapeutic strategies for neurodegenerative disorders.Annals of medicine · 2026Review
- Review
- Review
- Potentiated Maturation of hPSC-Derived Dopaminergic Neurons via Convergent Genetic and Small Molecule Modulation.Tissue engineering and regenerative medicine · 2026Article
- CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.Nature genetics · 2026Article
- Neuronal Antibodies in Patients With Atypical Parkinsonism.Neurology(R) neuroimmunology & neuroinflammation · 2026Observational
- Article
- Article
- Dynamic neuro-immune regulation of psychiatric risk loci in human neurons.Nature communications · 2026Article
- Variable Expressiveness of a Novel PathogenicDiseases (Basel, Switzerland) · 2026Article
- Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development.Neuron · 2026Article
- From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.Trends in neurosciences · 2026Review
- Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis.The EMBO journal · 2026Article
- Article
- Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.Stem cell reports · 2026Article
- Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.Cell stem cell · 2026Article
- Brain organoids and genome editing: A new era in understanding human brain development and disorders.Neural regeneration research · 2026Article
- Article
- Kdm6b-mediated epigenetic coordination of temporal precision during motor neuron differentiation.EMBO reports · 2026Article
- De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity.Nature communications · 2026Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 3 countries.
Gabriele CiceriThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. cicerig@mskcc.org.ORCID 0000-0002-8481-9771
Arianna BaggioliniThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-2476-561X
Hyein S ChoThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-3166-585X
Meghana KshirsagarComputational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Silvia Benito-KwiecinskiThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ryan M WalshThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kelly A AromolaranDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Alberto J Gonzalez-HernandezDepartment of Biochemistry, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2817-2475
Hermany MungubaDepartment of Biochemistry, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8480-8423
So Yeon KooThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8634-7643
Nan XuThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kaylin J SevillaThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peter A GoldsteinDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-5973-9104
Joshua LevitzDepartment of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
Christina S Leslie *Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4571-5910
Richard P Koche *Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6820-5083
Lorenz StuderThe Center for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. studerl@mskcc.org.ORCID 0000-0003-0741-7987
Memorial Sloan Kettering Cancer Center · USCornell University · USMicrosoft (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNovel strategies for induction of aging in human PSC-derived lineages for modeling Alzheimer's DiseaseR01AG054720 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI Doron Betel, LORENZ P. STUDER · 2017 to 2026
$4.5MCell Intrinsic and Extrinsic Factors Driving Maturation in Human PSC-derived NeuronsR01NS128087 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LORENZ P. STUDER · 2023 to 2026
$2.6MProgramming age in iPS models of Alzheimer's diseaseR01AG056298 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI STUDER, LORENZ P. · 2017 to 2021
$2.2MProbing schizophrenia associated neurodevelopmental defects in integrated neocortical organoidsF32MH116590 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI WALSH, RYAN · 2019 to 2021
$208kNCI NIH HHS P30 CA008748NIA NIH HHS R01 AG054720NIA NIH HHS R01 AG056298NIMH NIH HHS F32 MH116590NINDS NIH HHS R01 NS128087
Abstract
The pace of human brain development is highly protracted compared with most other species
Indexed as
Epigenesis, GeneticGene Expression Regulation, DevelopmentalHuman Embryonic Stem CellsNeural Stem CellsNeurogenesisNeuronsAdultAnimalsEnhancer of Zeste Homolog 2 ProteinHistocompatibility AntigensHistone-Lysine N-MethyltransferaseHumansMiceTime FactorsTranscription, GeneticDOT1L protein, humanEHMT1 protein, humanEHMT2 protein, humanEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanHistocompatibility AntigensHistone-Lysine N-Methyltransferase
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.