ArticleTherapeutic advances in neurological disorders2024
Intrinsic brain activity differences in perampanel-responsive and non-responsive drug-resistant epilepsy patients: an EEG microstate analysis.
Article in Therapeutic advances in neurological disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Altered EEG Microstate Dynamics in First Unprovoked Seizure and Newly Diagnosed Epilepsy Patients.European journal of neurology · 2025Article
- Identification of topological alterations using microstate dynamics in patients with infantile epileptic spasms syndrome.Scientific reports · 2025Article
- Concurrent functional-structural reorganization in brain networks of AVM patients: a functional and structural study.Frontiers in neurology · 2025Article
- A comprehensive prediction model of drug-refractory epilepsy based on combined clinical-EEG microstate features.Therapeutic advances in neurological disorders · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Drug-resistant epilepsy (DRE) patients exhibit aberrant large-scale brain networks. Perampanel may be a therapeutic option for controlling seizures in these patients. Objective: We aim to explore the differences of resting-state electroencephalogram (EEG) microstate in perampanel-responsive and non-responsive DRE patients. Design: Retrospective study. Methods: Clinical data were collected from DRE patients who received perampanel treatment at the Fujian Medical University Union Hospital from June 2020 to September 2021, with a minimum follow-up of 6 months. Patients were classified into three groups based on the extent of reduction in seizure frequency: non-responsive (seizure reduction <50%), responsive (seizure reduction >50% but not seizure-free), and seizure-free. Resting-state EEG data sets of all participants were subjected to EEG microstate analysis. The study comprehensively compared the mean duration, frequency per second, and temporal coverage of each microstate among the three groups. Results: A total of 76 perampanel-treated DRE patients were categorized into three groups based on their response to treatment: non-responsive ( Conclusion: Microstate A, B, and D is associated with the sensorimotor network, visual network, salience network, and attention network, respectively. This study demonstrates statistically significant differences in the sensorimotor, visual, and salience networks, but not in the attention network, between perampanel-responsive and non-responsive DRE patients.
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