ReviewJournal of experimental botany2024
The ascorbate biosynthesis pathway in plants is known, but there is a way to go with understanding control and functions.
Review in Journal of experimental botany, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Identification of poplar and spruce GDP-mannose pyrophosphorylases involved in mannan and ascorbic acid biosynthesis.Tree physiology · 2026Article
- The Circadian Oscillator Affects Both Glutathione Homeostasis and Its Response to Salt Stress in Arabidopsis thaliana.Plant, cell & environment · 2026Article
- Review
- Antioxidant strategies of four native tree species across seasons in urban and peri-urban Atlantic Forest remnants.Environmental monitoring and assessment · 2026Article
- Diel-driven variations of leaf dark respiration and metabolite levels in C3 and C4 grasses.Plant physiology · 2026Article
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Review
- Comparison of Selected Pro-Health Biologically Active Chemical Compounds inMolecules (Basel, Switzerland) · 2026Article
- Electron currents mediated by tonoplast cytochromes b561.European biophysics journal : EBJ · 2026Review
- Review
- Effects of Climatic Conditions and Genotypes on Vitamin C Levels in Stone Species and Apple Cultivars.Plants (Basel, Switzerland) · 2026Article
- PpCML14 from Kentucky bluegrass confers drought and salinity tolerance in transgenic rice.Plant cell reports · 2026Article
- Natural novel vitamin C derivative, 2-Chinese herbal medicines · 2026Review
- Intraspecific Variation in Drought and Nitrogen-Stress Responses in Pedunculate Oak (Plants (Basel, Switzerland) · 2025Article
- Integrated physiological, biochemical and transcriptomic analyses revealed key genes regulating ascorbic acid biosynthesis during sweet potato development.Food chemistry. Molecular sciences · 2025Article
- Origin and evolution of signaling pathways responsible for ascorbic acid synthesis and catabolism during plant terrestrialization.Horticulture research · 2025Article
- Comprehensive evaluation of compound saline-alkali tolerance and gene mining by GWAS in Vicia faba L.BMC plant biology · 2025Article
- Biofortification of potato nutrition.Journal of advanced research · 2025Review
- Molecular mechanisms of high levels of L-ascorbic acid accumulation in chestnut rose fruits.Plant communications · 2025Article
- Silicon application improves tomato yield and nutritional quality.BMC plant biology · 2025Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Ascorbate (vitamin C) is one of the most abundant primary metabolites in plants. Its complex chemistry enables it to function as an antioxidant, as a free radical scavenger, and as a reductant for iron and copper. Ascorbate biosynthesis occurs via the mannose/l-galactose pathway in green plants, and the evidence for this pathway being the major route is reviewed. Ascorbate accumulation is leaves is responsive to light, reflecting various roles in photoprotection. GDP-l-galactose phosphorylase (GGP) is the first dedicated step in the pathway and is important in controlling ascorbate synthesis. Its expression is determined by a combination of transcription and translation. Translation is controlled by an upstream open reading frame (uORF) which blocks translation of the main GGP-coding sequence, possibly in an ascorbate-dependent manner. GGP associates with a PAS-LOV protein, inhibiting its activity, and dissociation is induced by blue light. While low ascorbate mutants are susceptible to oxidative stress, they grow nearly normally. In contrast, mutants lacking ascorbate do not grow unless rescued by supplementation. Further research should investigate possible basal functions of ascorbate in severely deficient plants involving prevention of iron overoxidation in 2-oxoglutarate-dependent dioxygenases and iron mobilization during seed development and germination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.