Evidence map›Paper›PMID 38300640›Full record

ArticleAging and disease2024

Association of Plasma Markers of Alzheimer's Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging.

Mustapha Bouhrara, Keenan A Walker, Joseph S R Alisch, Zhaoyuan Gong, Caio H Mazucanti, Alexandria Lewis, Abhay R Moghekar, Lisa Turek, Victoria Collingham, Nader Shehadeh and 6 more

Open access · goldAbstract read
In one paragraph

Article in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  4. Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Review
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  7. Microglial Feimin Alleviates Cognitive Impairment in High-Fat Diet-Fed Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Mustapha BouhraraLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Joseph S R AlischLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Zhaoyuan GongLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Caio H MazucantiLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Alexandria LewisJohns Hopkins University School of Medicine, Baltimore, 21224 MD, USA.
Abhay R MoghekarJohns Hopkins University School of Medicine, Baltimore, 21224 MD, USA.
Lisa TurekClinical Research Core, Baltimore, MD 21224, USA.
Victoria CollinghamClinical Research Core, Baltimore, MD 21224, USA.
Nader ShehadehClinical Research Core, Baltimore, MD 21224, USA.
Giovanna FantoniClinical Research Core, Baltimore, MD 21224, USA.
Mary KailehClinical Research Core, Baltimore, MD 21224, USA.
Christopher M BergeronLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Jan BergeronLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Josephine M EganLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
National Institutes of Health · USUniversity of Maryland, Baltimore · USNational Institute on Aging · USJohns Hopkins Medicine · US

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
GESTALT-Genetic and Epigenetic Signatures of Translational Aging Laboratory TestingZIAAG000996 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2015 to 2025
$7.6M
NIA NIH HHS P30 AG066507
6 · The paper itself

Abstract

The choroid plexus (CP) is a vital brain structure essential for cerebrospinal fluid (CSF) production. Moreover, alterations in the CP's structure and function are implicated in molecular conditions and neuropathologies including multiple sclerosis, Alzheimer's disease, and stroke. Our goal is to provide the first characterization of the association between variation in the CP microstructure and macrostructure/volume using advanced magnetic resonance imaging (MRI) methodology, and blood-based biomarkers of Alzheimer's disease (Aß

Indexed as

AgingAlzheimer DiseaseBiomarkersChoroid PlexusMagnetic Resonance ImagingAdultAgedAged, 80 and overAmyloid beta-PeptidesCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeuroinflammatory Diseasestau ProteinsAmyloid beta-PeptidesBiomarkerstau Proteins

Identifiers

PMID38300640
PMCPMC11346414
OpenAlexW4390820729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.