ArticleImmunity2024
Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
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Who cites it
40 citing papers in PubMed, 43 citations in OpenAlex.
- Phase 2 study of azacitidine plus pembrolizumab as second-line treatment in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma.The oncologist · 2026Trial
- The ADAP-TRIM21-ZEB2 axis regulates CD8iScience · 2026Article
- Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism.PLoS pathogens · 2026Article
- Phased fragility and stability of non-genetic B cell states in the germinal center accelerate the genetic evolution of antibodies.Cell systems · 2026Article
- GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors.Signal transduction and targeted therapy · 2026Article
- Upregulation of TCF1 and BCL11B in CD8+ effector T cells predicts favorable response to ibrutinib in patients with chronic lymphocytic leukemia.Communications biology · 2026Article
- Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.bioRxiv : the preprint server for biology · 2026Article
- Design principles of the cytotoxic CD8Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functions and features of circulating memory T cells.Immunity · 2026Review
- Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8Research square · 2026Article
- Optimal transport fate mapping resolves T cell differentiation dynamics across tissues.bioRxiv : the preprint server for biology · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- A convenient single-cell assay for the newly synthesized transcriptome reveals FLI1 regulon downregulation during T cell activation.Cell reports methods · 2026Article
- Intermittent Tacrolimus Treatment Delays CD8+ Tumor-Infiltrating Lymphocyte Exhaustion and Enhances PD1 Blockade Therapy in Melanoma-Bearing Mice.Journal of immunology research · 2026Article
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
- Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence.BMC biology · 2025Article
- The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8Immunity · 2025Article
- Design principles of the cytotoxic CD8bioRxiv : the preprint server for biology · 2025Article
- Design principles of the cytotoxic CD8ArXiv · 2025Article
- Pre-division TCF1 drop determines long-term CD8 T cell fates.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Kathleen AbadieDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Elisa C ClarkDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Rajesh M ValanparambilEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Obinna UkoguDepartment of Applied Mathematics, University of Washington, Seattle, WA 98105, USA.
Wei YangDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Riza M DazaDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Kenneth K H NgDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Jumana FathimaDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Allan L WangDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Judong LeeEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Tahseen H NastiEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Avinash BhandoolaT-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Armita NourmohammadDepartment of Applied Mathematics, University of Washington, Seattle, WA 98105, USA; Department of Physics, University of Washington, Seattle, WA 98105, USA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: shendure@uw.edu.
Junyue CaoDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Laboratory of Single-Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY 10065, USA. Electronic address: jcao@rockefeller.edu.
Hao Yuan KuehDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: kueh@uw.edu.
University of Washington · USEmory University · USHoward Hughes Medical Institute · USNational Cancer Institute · USUniversity of Washington Applied Physics Laboratory · US
Funding
T cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5MVersatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9MT CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2MLearning a molecular shape space for the adaptive immune systemR35GM142795 · NIGMS · UNIVERSITY OF WASHINGTON · PI NOURMOHAMMAD, ARMITA · 2021 to 2025
$1.8MInput encoding in T-cell receptor signalingR21EB027327 · NIBIB · UNIVERSITY OF WASHINGTON · PI KUEH, HAO YUAN · 2019 to 2021
$622kNHGRI NIH HHS R01 HG010632NIAID NIH HHS R01 AI030048NIBIB NIH HHS R21 EB027327NIGMS NIH HHS R35 GM142795
Abstract
The immune system encodes information about the severity of a pathogenic threat in the quantity and type of memory cells it forms. This encoding emerges from lymphocyte decisions to maintain or lose self-renewal and memory potential during a challenge. By tracking CD8
Indexed as
CD8-Positive T-LymphocytesMemory T CellsCell DifferentiationClone CellsEpigenesis, GeneticImmunologic Memoryacute infectioncell fate decisionsimmune memorylineage plasticitylive-cell imagingmathematical modelingsingle-cell dynamicssystems immunologyT cell differentiationtime-resolved single-cell RNA-seq
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What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.