Evidence map›Paper›PMID 38308203›Full record

Trial reportBMC ophthalmology2024

Study on the correlation between iris blood flow, iris thickness and pupil diameter in the resting state and after pharmacological mydriasis in patients with diabetes mellitus.

Lipu Cui, Ying Xiao, Zhaoyu Xiang, Zhangling Chen, Chenhao Yang, Haidong Zou

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03631108 (Feasibility Study and Preliminary Application Study on Noninvasive Iris Optical Coherence Tomography Angiography), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03631108 unknown statusnot on this map

Feasibility Study and Preliminary Application Study on Noninvasive Iris Optical Coherence Tomography Angiography (OCTA)

TypeobservationalSponsorShanghai Eye Disease Prevention and Treatment CenterRan2018 to 2019Enrolled4,000ConditionsConjunctivitis, Glaucoma, Myopia, Diabetic RetinopathyArmsOCTA (ZEISS)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Computational study of DurystaDrug delivery and translational research · 2026
    Article
  3. Review
  4. Article
  5. Comparative analysis of iridian anterior segment OCT and microbiological features in Fuchs Uveitis Syndrome and Posner-Schlossman Syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lipu Cui *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, Shanghai, China.
Ying Xiao *Department of Ophthalmology, Children's Hospital of Fudan University, No. 399 Wanyuan Road, 201102, Shanghai, China.
Zhaoyu XiangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, Shanghai, China.
Zhangling ChenDepartment of Ophthalmology, Shanghai Songjiang District Central Hospital, Shanghai, China.
Chenhao YangDepartment of Ophthalmology, Children's Hospital of Fudan University, No. 399 Wanyuan Road, 201102, Shanghai, China. ychben@hotmail.com.
Haidong ZouDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, Shanghai, China. zouhaidong@sjtu.edu.cn.

Funding

Chinese National key research and development program 2021YFC2702100Shanghai engineering research center of precise diagnosis and treatment of eye diseases, Shanghai, China 19DZ2250100
6 · The paper itself

Abstract

backgroundTo investigate whether iris blood flow and iris thickness at the iris smooth muscle region affect the pupil diameter at rest and after drug-induced mydriasis in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).

methodsT1DM patients and healthy children were recruited from the SCADE cohort. T2DM patients and healthy adults were recruited from patients undergoing cataract surgery at Shanghai General Hospital. Iris vessel density, pupil diameter (PD) and iris thickness were measured in both the resting and drug-induced mydriasis states. Iris vessel density was measured by optical coherence tomography angiography (OCTA), PD was measured by a pupilometer, and iris thickness at the iris smooth muscle regions were measured using anterior segment optical coherence tomography (AS-OCT).

resultsThe study included 34 pediatric T1DM patients and 50 adult T2DM patients, both groups without diabetic retinopathy, and age-sex-matched healthy controls. At baseline, T1DM children and healthy children showed no differences in iris blood flow, iris thickness, or PD. However, the adult T2DM group exhibited higher vessel density at the pupil margin, thinner iris thickness at the iris dilator region, and smaller PD compared to healthy adults, with these differences being statistically significant (P < 0.05). After pupil dilation, there were no changes in iris blood flow and PD in the T1DM group compared to healthy children, whereas the T2DM group showed a significantly smaller PD compared to healthy adults. Multivariate regression analysis revealed that in the T2DM group, glycated hemoglobin was an independent factor of PD after dilation (β=-0.490, p = 0.031), with no such factors identified in the T1DM group.

conclusionThe insufficiently dilated pupil diameter after drug-induced mydriasis is correlated to the level of glycated hemoglobin among T2DM patients.

trial registrationThe registration number on the clinical trial website was NCT03631108.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2MydriasisAdultChildChinaDilatation, PathologicFemaleGlycated HemoglobinHumansIntraocular PressureIrisMalePupilTomography, Optical CoherenceGlycated Hemoglobiniris blood flowiris thicknessPupil abnormalitiesType 1 diabetesType 2 diabetes

Identifiers

PMID38308203
PMCPMC10835944

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.