Evidence map›Paper›PMID 38309829›Full record

Trial reportThe American journal of clinical nutrition2024

Sustained effects of small-quantity lipid-based nutrient supplements provided during the first 1000 days on child growth at 9-11 y in a randomized controlled trial in Ghana.

Helena J Bentil, Seth Adu-Afarwuah, Elizabeth L Prado, Charles D Arnold, Paul D Hastings, Amanda E Guyer, Mavis O Mensah, Adom Manu, Xiuping Tan, Ebenezer Adjetey and 4 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970866 nacompletednot on this map

Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants

TypeinterventionalSponsorUniversity of California, DavisRan2009 to 2017Enrolled3,499ConditionsAnemia, Malnutrition, StuntingArmsIron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Helena J BentilDepartment of Nutrition, University of California-Davis, Davis, CA, United States. Electronic address: hjbentil@ucdavis.edu.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Elizabeth L PradoDepartment of Nutrition, University of California-Davis, Davis, CA, United States.
Charles D ArnoldDepartment of Nutrition, University of California-Davis, Davis, CA, United States.
Paul D HastingsDepartment of Psychology and Center for Mind and Brain, University of California-Davis, Davis, CA, United States.
Amanda E GuyerDepartment of Human Ecology and Center for Mind and Brain, University of California-Davis, Davis, CA, United States.
Mavis O MensahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Adom ManuDepartment of Population, Family & Reproductive Health, School of Public Health, University of Ghana, Accra, Ghana.
Xiuping TanDepartment of Nutrition, University of California-Davis, Davis, CA, United States.
Ebenezer AdjeteyDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Benjamin AmponsahDepartment of Psychology, University of Ghana, Accra, Ghana.
Maku E DemuyakorMcKing Consulting Corporation, Atlanta, GA, United States.
Kathryn G DeweyDepartment of Nutrition, University of California-Davis, Davis, CA, United States.
Brietta M OaksDepartment of Nutrition, University of Rhode Island, Kingston, RI, United States.
University of California, Davis · USUniversity of Ghana · GHMcKing Consulting (United States) · USUniversity of Rhode Island · US

Funding

Neural mechanisms of protective effects of early nutrition on the development of social-emotional difficulties among children in GhanaR01HD099811 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Paul David Hastings · 2019 to 2026
$4.1M
Investigation of a new sequential multiple hit model to examine risk and resilience in a prospective longitudinal cohort of children in GhanaR03HD104875 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HASTINGS, PAUL DAVID · 2022 to 2024
$159k
NICHD NIH HHS R01 HD099811NICHD NIH HHS R03 HD104875
6 · The paper itself

Abstract

backgroundThere is limited research on whether nutritional supplementation in the first 1000 d affects long-term child outcomes. We previously demonstrated that pre- and postnatal small-quantity lipid-based nutrient supplements (SQ-LNS) increased birth weight and child length at 18 mo of age in Ghana.

objectivesWe aimed to investigate the effect of pre- and postnatal SQ-LNS on child growth and blood pressure at 9-11 y.

methodsIn the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, 1320 females ≤20 weeks of gestation were randomly assigned to receive daily: iron and folic acid (IFA) during pregnancy and placebo during 6 mo postpartum or multiple micronutrients (MMNs) during pregnancy and 6 mo postpartum, or SQ-LNS during pregnancy and 6 mo postpartum and for their children aged from 6 to 18 mo. We re-enrolled 966 children aged 9-11 y and assessed child blood pressure, height-for-age z-score (HAZ), body mass index (BMI)-for-age z-score, waist-to-height ratio, triceps skinfold, and midupper arm circumference. We compared SQ-LNS with control (IFA + MMN) groups adjusting for child's age.

resultsMean (standard deviation [SD]) HAZ in SQ-LNS and control group was -0.04 (0.96) and -0.16 (0.99); P = 0.060. There were no indications of group differences in the other outcomes (P > 0.10). Effects on HAZ varied by child sex (P-interaction = 0.075) and maternal prepregnancy BMI (kg/m

conclusionsThere is a sustained impact of prenatal and postnatal SQ-LNS on linear growth among female children and children whose mothers were not overweight. This trial was registered at clinicaltrials.gov as NCT00970866 (https://clinicaltrials.gov/ct2/show/record/NCT00970866).

Indexed as

LipidsMicronutrientsChildDietary SupplementsFemaleFolic AcidGhanaHumansInfantIronMaleMothersPregnancyFolic AcidIronLipidsMicronutrients1000 daysearly adolescenceGhanagrowthlipid-based nutrient supplements

Identifiers

PMID38309829
PMCPMC10884609
OpenAlexW4390414034

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.