ArticleJournal of affective disorders reports2024
Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions.
Article in Journal of affective disorders reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.Neuroscience letters · 2025Trial
- The role of reduced sense of isolation in group-format PTSD treatment.Scientific reports · 2026Article
- Neural correlates of meditation-induced changes in self-related traits: a resting state fMRI study.Mindfulness · 2026Article
- Remote Mindfulness Training for Health Following Early Life Adversity: A Randomized Controlled Feasibility Trial.Behavior therapy · 2026Article
- Non-attachment as a potential mechanism for the effects of mindfulness meditation on obsessive-compulsive symptoms among survivors of adverse childhood experiences.Current psychology (New Brunswick, N.J.) · 2025Article
- Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry.Journal of mood and anxiety disorders · 2025Article
- Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.Journal of neuroendocrinology · 2025Article
- Mindfulness-based interventions for preventing childhood maltreatment and restoring health among survivors: a public health perspective.Mindfulness · 2025Article
- Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.Journal of mood and anxiety disorders · 2025Article
- Psychological assessments, allostatic load and gene expression analyses in a randomized controlled trial comparing meditation, yoga, and stress education.Frontiers in psychology · 2025Article
- Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: preliminary insights from an opioid use disorder study.Frontiers in psychology · 2025Article
- Shedding Light on the Aftermath: Childhood Maltreatment's Role in Modifying the Association Between Recent Life Stress and Resting-State Network Connectivity.Behavioral sciences (Basel, Switzerland) · 2024Article
- Temporal dynamics and long-term effects of a mindfulness-based intervention for young adults with adverse childhood experiences.Mindfulness · 2024Article
- Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors.Journal of affective disorders reports · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Adverse Childhood Experience (ACE) has been shown to have detrimental impact on amygdala structure. Prior research found that adaptive psychological changes after Mindfulness-Based Interventions (MBI) were associated with amygdala volumetric changes. The present study aims to further investigate whether such effects also occur among ACE survivors and whether the effects are unique to MBI. Methods: A total of 64 young adult childhood adversity survivors were randomized to an eight-week MBI or Stress Management Education (SME) as an active control condition. Anatomical MRI and questionnaires on mindfulness, stress and psychological health were collected at baseline and post-intervention. Due to subject dropout, the final sample included 39 subjects (MBI:20, SME:19). Results: Both groups showed increased mindfulness levels, reduced stress, and improved psychological symptoms (depression, anxiety, and somatization), with no significant group by time interaction effect. There was no significant group difference on amygdala volumetric changes. Within the MBI group, childhood maltreatment severity was a significant mediator between changes of mindfulness levels and Limitations: Modest sample size, relatively low retention rates, suboptimal monitoring of home practice. Conclusions: MBI did not demonstrate overall better clinical effects than SME. Psychological-change-dependent amygdala volumetric change was not specific to MBI. Childhood maltreatment severity modulated the relationships between adaptive psychological changes and amygdala volumetric changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.