SynthesisNeuropsychology review2025
Change in Cognitive Function over the Course of Major Depressive Disorder: A Systematic Review and Meta-analysis.
Synthesis in Neuropsychology review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07703722 (Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial
Who cites it
17 citing papers in PubMed.
- Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study.BMJ mental health · 2025Trial
- No Cognitive Scarring Over 20 Years in Recurrent Depression: Bidirectionality of Cognitive Functioning and Depression.Clinical psychology in Europe · 2026Article
- Bidirectional Associations Between Depressive Symptoms and Cognitive Functioning in Older Adults: Heterogeneity by Grandparenthood Status.Journal of Intelligence · 2026Article
- Associations Between Cognitive Functions and Subsequent Mood Disorder Prognosis in Low-Risk, High-Risk and Affected Monozygotic Twins: A Seven-Year Follow-Up Study.Acta psychiatrica Scandinavica · 2026Article
- Cognitive function in long-term survivors after treatment for brain metastases compared with normative samples.Neuro-oncology practice · 2026Article
- Effects of serum hypersensitive C-reactive protein and BMI on cognitive dysfunction in first-episode and drug-naive patients with major depressive disorder.BMC psychiatry · 2026Article
- Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.Brain topography · 2025Article
- The relationship between cognitive impairment and acoustic features in major depressive disorder: a longitudinal cohort study.BMC psychiatry · 2025Article
- Predicting cognitive functioning in mood disorders through smartphone typing dynamics.Journal of psychopathology and clinical science · 2025Article
- Cognitive deficits in treatment-resistant depression: protocol for a systematic review and meta-analysis.BMJ open · 2025Article
- Insights on the cognitive enhancement effect of desvenlafaxine in major depressive disorder.Annals of general psychiatry · 2025Article
- Clinical practice guidelines - An overview of cognitive remediation for various neuropsychiatric disorders.Indian journal of psychiatry · 2025Article
- Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function.Frontiers in psychiatry · 2025Article
- Excessive propagation of right frontal beta oscillations in patients with a history of major depressive disorder.Biomedical engineering letters · 2025Article
- Verbal memory in major depressive disorder in a long-term perspective: a five-year longitudinal study of first episode patients.Frontiers in psychiatry · 2025Article
- The mediating role of anxiety and depressive symptoms on the relationship between physical limitations and cognitive impairment among older adults in China: differences based on religious perspective.Frontiers in psychology · 2025Article
- Improvement of persistent impairments in executive functions and attention following electroconvulsive therapy in a case control longitudinal follow up study.BMC psychiatry · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Major depressive disorder (MDD) is associated with significant cognitive deficits during the acute and remitted stages. The aim of this systematic review and meta-analysis was to examine the course of cognitive function whilst considering demographic, treatment, or clinical features of MDD that could moderate the extent of cognitive change. Databases were searched to identify studies that reported on cognitive function in MDD with a ≥12-week test-retest interval. Relevant studies were pooled using random effects modelling to generate an inverse-variance, weighted, mean effect size estimate (Hedges' g) of cognitive change for each cognitive variable and for an overall composite cognitive domain. Of 6898 records, 99 eligible studies were identified from which 69 were meta-analysed, consisting of 4639 MDD patients (age
Indexed as
Identifiers
38315296What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.