Evidence map›Paper›PMID 38317466›Full record

ArticleRecent advances in anti-infective drug discovery2024

Synthesis of Ursolic Acid-based Hybrids:

Vuyolwethu Khwaza, Samson Olaitan Oselusi, Eric Morifi, Mutshinyalo Nwamadi, Kamogelo S Hlope, Derek Tantoh Ndinteh, Thabe Moses Matsebatlela, Opeoluwa Oyehan Oyedeji, Blessing Atim Aderibigbe

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Article in Recent advances in anti-infective drug discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vuyolwethu KhwazaDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape, South Africa.ORCID 0000-0003-4875-1535
Samson Olaitan OselusiSchool of Pharmacy, University of the Western Cape, Bellville, Cape Town 7535, South Africa.
Eric MorifiSchool of Chemistry, Mass Spectrometry Division, University of Witwatersrand, Johannesburg, South Africa.
Mutshinyalo NwamadiDepartment of Chemistry, University of Johannesburg, Auckland Park Campus, Johannesburg, South Africa.
Kamogelo S HlopeDepartment of Biochemistry, Microbiology and Biotechnology, Faculty of Science and Agriculture, University of Limpopo, South Africa.
Derek Tantoh NdintehDepartment of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa.
Thabe Moses MatsebatlelaDepartment of Biochemistry, Microbiology and Biotechnology, Faculty of Science and Agriculture, University of Limpopo, South Africa.
Opeoluwa Oyehan OyedejiDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape, South Africa.
Blessing Atim AderibigbeDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape, South Africa.ORCID 0000-0003-1157-7481

Funding

Govan Mbeki Research and Development Centrem, University of Fort HareSasolSouth African Medical Research Council
6 · The paper itself

Abstract

backgroundThere is a critical need for the discovery of novel and effective antibacterial or anticancer molecules.

objectivesAmine-linked ursolic acid-based hybrid compounds were prepared in good yields in the range of 60-68%.

methodsTheir molecular structures were successfully confirmed using different spectroscopic methods including

resultTheir antibacterial efficacy was evaluated against eleven bacterial pathogens using a serial dilution assay. Majority of the bacterial strains were inhibited significantly by compounds 17 and 24, with the lowest MIC values in the range of 15.3-31.25 μg/mL. Compound 16 exhibited higher cytotoxicity against HeLa cells than ursolic acid, with an IC

conclusionThe in vitro antibacterial activity and cytotoxicity of these hybrid compounds demonstrated that ursolic acid-based hybrid molecules are promising compounds. Further research into ursolic acid-based hybrid compounds is required.

Indexed as

Anti-Bacterial AgentsMicrobial Sensitivity TestsTriterpenesUrsolic AcidAntineoplastic AgentsBacteriaCell Line, TumorComputer SimulationHeLa CellsHumansMCF-7 CellsStructure-Activity RelationshipAnti-Bacterial AgentsAntineoplastic AgentsTriterpenesUrsolic Acidantibacterialanticancercytotoxicity.hybrid moleculesSynthesisursolic acid

Identifiers

PMID38317466

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.