ArticleReports of biochemistry & molecular biology2023
Relationship Between Red Cell Distribution Width and Oxidative Stress Indexes in Patients with Coronary Artery Disease.
Article in Reports of biochemistry & molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Elevated red cell distribution width as a prognostic indicator in critically ill patients with atrial fibrillation and chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD.BMC gastroenterology · 2026Article
- Article
- A New and Robust Prognostic Biomarker for Mortality Risk Prediction in Dialysis Patients With Coronary Artery Disease: Red Cell Distribution Width-to-Albumin Ratio.Reviews in cardiovascular medicine · 2026Article
- Elevated Red Blood Cell Distribution Width Predicts Mortality and Major Adverse Cardiovascular Events After Acute Myocardial Infarction: A Large Propensity Score-Matched Cohort Study.Journal of clinical medicine · 2026Article
- Longitudinal metabolomics study of phosphate-adenine-guanosine-glucose-saline-mannitol stored red blood cells.Transfusion · 2026Article
- Article
- Hemoglobin-to-Red Cell Distribution Width Ratio and Vitamin D Status as Early Predictors of Cardiovascular Risk in Primary Sjögren's Syndrome.Life (Basel, Switzerland) · 2026Article
- Relationship between persistent atrial fibrillation in high-altitude regions and left atrial diameter, red cell distribution width, and NT-ProBNP: a retrospective case-control study.Frontiers in cardiovascular medicine · 2026Article
- Observational
- High red blood cell distribution width associated with incident frailty in patients with cardiometabolic diseases: A longitudinal study.Scientific reports · 2025Article
- One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999-2002.The American journal of clinical nutrition · 2025Article
- Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications.World journal of diabetes · 2025Review
- Article
- Red blood cell distribution width to albumin ratio and urinary incontinence subtypes in NHANES 2007-2018.Scientific reports · 2025Article
- Article
- Machine Learning Efficiency in Predicting Obstructive Coronary Artery Disease in Patients with Non-ST Elevation Acute Coronary Syndrome in the First Hours of Admission.Sovremennye tekhnologii v meditsine · 2025Article
- Article
- Integrated risk factors for premature acute coronary syndrome: residual cholesterol, RDW, and BMI.Frontiers in cardiovascular medicine · 2025Article
- Pro-Oxidant/ Antioxidant Balance Correlates with Red Blood Cell Indices and Anemia Severity in the Anemic Patients.Reports of biochemistry & molecular biology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Red blood cell distribution (RDW), an index of the size variability of erythrocytes, is significantly associated with coronary stenosis and can strongly predict the mortality risk in coronary artery disease (CAD). The biological mechanisms involved are not fully understood but may include oxidative stress. We sought to investigate the relationship between RDW and markers of oxidative stress in patients with CAD. Methods: Participants were 112 consecutive patients referred to department of cardiac surgery for evaluation of chest pain. 32 patients had stable CAD, 40 patients had unstable CAD and 40 subjects were diagnosed as non-CAD. The levels of lipid peroxidation (TBARS) were measured in plasma and membrane samples by a fluorometric method. The plasma levels of glutathione (GSH) and total antioxidant capacity (TAC) were determined using spectrophotometric methods. Results: Lipid peroxidation levels were significantly higher in the erythrocyte membrane of stable CAD patients than non-CAD patients. The levels of TAC were significantly lower in both stable and unstable groups when compared to that of the control group (P< 0.019 and P< 0.001, respectively), but did not differ between stable and unstable CAD. In addition, there was no significant difference in the serum GSH levels among the study groups. Membrane TBARS was directly associated with RDW in three groups of study. Conclusions: We found an independent association between RDW levels and membrane lipid peroxidation in patients with CAD. This finding suggests that oxidative stress may be a potential underlying biological mechanism for increased RDW in CAD patients.
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