Evidence map›Paper›PMID 38318136›Full record

ArticleFrontiers in pharmacology2024

Dual inhibition of MEK and PI3Kβ/δ-a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer.

Vicenç Ruiz de Porras, Adrià Bernat-Peguera, Clara Alcon, Fernando Laguia, Maria Fernández-Saorin, Natalia Jiménez, Ana Senan-Salinas, Carme Solé-Blanch, Andrea Feu, Mercedes Marín-Aguilera and 5 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vicenç Ruiz de Porras *CARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Adrià Bernat-Peguera *CARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Clara Alcon *Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.
Fernando LaguiaIrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
Maria Fernández-SaorinCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Natalia JiménezTranslational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
Ana Senan-SalinasCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Carme Solé-BlanchCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Andrea FeuDepartment of Pathology, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain.
Mercedes Marín-AguileraTranslational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
Juan Carlos PardoCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Maria Ochoa-de-OlzaCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.
Joan MonteroDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.
Begoña MelladoTranslational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
Albert FontCARE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AZD8186metastatic castration-resistant prostate cancerPTEN statusselumetinibtaxane resistance

Identifiers

PMID38318136
PMCPMC10838968

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.