Evidence map›Paper›PMID 38321808›Full record

ArticleESC heart failure2024

MicroRNAs are associated with cardiac biomarkers, cardiac structure and function and incident outcomes in heart failure.

Aferdita Spahillari, Laurel Jackson, Dimitrios Varrias, Sam A Michelhaugh, James L Januzzi, Bobby Shahideh, David Daghfal, Nedyalka Valkov, Gillian Murtagh, Saumya Das

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. What is new in cardiac anesthesia in 2024?Journal of anesthesia and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aferdita SpahillariDepartment of Medicine, Division of Cardiology, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0002-9157-5648
Laurel JacksonAbbott Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA.
Dimitrios VarriasAlbert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, USA.
Sam A MichelhaughGeorgetown University School of Medicine, Washington, DC, USA.
James L JanuzziDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA, 02114, USA.
Bobby ShahidehAbbott Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA.
David DaghfalAbbott Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA.
Nedyalka ValkovDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA, 02114, USA.
Gillian MurtaghAbbott Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA.
Saumya DasDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA, 02114, USA.ORCID https://orcid.org/0000-0002-4521-4606

Funding

Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failureR35HL150807 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Saumya Das · 2020 to 2026
$6.7M
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2M
Molecular dissection and imaging of extracellular vesicles to define their origin and targetsUH3TR002878 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, TALISMAN, TIJANA · 2021 to 2022
$2.2M
Novel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1M
Abbott LaboratoriesHutter Family ProfessorshipNCATS NIH HHS UH3 TR000901NCATS NIH HHS UH3 TR002878NHLBI NIH HHS R01 HL122547NHLBI NIH HHS R35 HL150807NIH HHS R01 HL122547NIH/NCAT UH3TR000901
6 · The paper itself

Abstract

aimsThe association between microRNAs (miRNAs) and established cardiac biomarkers is largely unknown. We aimed to measure the association between plasma miRNAs and N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin I, soluble urokinase-type plasminogen activator receptor (suPAR), and galectin-3 with cardiac structure and function and clinical outcomes. METHODS AND

resultsWe quantified 32 plasma miRNAs using the FirePlex miRNA assay and measured biomarkers in 139 individuals with symptomatic heart failure (HF). We used principal component (PC) analysis and linear regression to evaluate the association between miRNAs and biomarkers with ventricular size and function by echocardiography and Cox modelling for the incidence of a first composite event of HF hospitalization, heart transplant, left ventricular assist device implant, or death. The mean (standard deviation) age at baseline was 64.3 (12.4) years, 33 (24%) were female, and 122 (88%) were White. A total of 45 events occurred over a median follow-up of 368 (interquartile range 234, 494) days. Baseline NT-proBNP (β = -2.0; P = 0.001) and miRNA PC2 (β = 2.6; P = 0.002) were associated with baseline left ventricular ejection fraction. NT-proBNP (β = 20.6; P = 0.0004), suPAR (β = -39.6; P = 0.005), and PC4 (β = 21.1; P = 0.02) were associated with baseline left ventricular end-diastolic volumes. NT-proBNP [hazard ratio (HR) 1.67, 95% confidence interval (CI) 1.28-2.18, P = 0.0002], galectin-3 (HR 2.02, 95% CI 1.05-3.91, P = 0.036), PC3 (HR 1.75, 95% CI 1.23-2.49, P = 0.002), and PC4 (HR 1.67, 95% CI 1.1-2.52, P = 0.016) were independently associated with incident events.

conclusionsBiomarkers and miRNA PCs are associated with cardiac structure and function and incident cardiovascular outcomes. Combining information from miRNAs provides prognostic information beyond biomarkers in HF.

Indexed as

BiomarkersHeart FailureMicroRNAsNatriuretic Peptide, BrainAgedEchocardiographyFemaleFollow-Up StudiesGalectin 3GalectinsHeart VentriclesHumansIncidenceMaleMiddle AgedPeptide FragmentsBiomarkersGalectin 3GalectinsMicroRNAsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Receptors, Urokinase Plasminogen ActivatorTroponin IBiomarkersCardiac remodellingHeart failure outcomesMicroRNAs

Identifiers

PMID38321808
PMCPMC11098646

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.