Evidence map›Paper›PMID 38321902›Full record

SynthesisCurrent medicinal chemistry2024

Therapeutic Potential of Iron Chelators in Viral Diseases: A Systematic Review.

Maryam Shamseddini Lori, Azade Kalantari Khandani, Gholamreza Dehghannoudeh, Mandana Ohadi, Mehdi Ansari

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam Shamseddini LoriDepartment of Pharmaceutics, Faculty of Pharmacy, Kerman Medical Science University, Kerman, Iran.
Azade Kalantari KhandaniDepartment of Pharmaceutics, Faculty of Pharmacy, Kerman Medical Science University, Kerman, Iran.
Gholamreza DehghannoudehPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mandana OhadiPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mehdi AnsariDepartment of Drug and Food Control, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Funding

Kerman University of Medical Sciences
6 · The paper itself

Abstract

backgroundIron chelators (ICs) have recently emerged as one of the new methods of treatment for viral infections. This study aimed to evaluate the efficiency and safety of natural ICs compared to synthetic ICs. Natural and synthetic ICs are the most common therapeutic agents tested for the treatment of viral infections. When evaluated against synthetic ICs, natural ICs are probably favored owing to their lower toxicity and safer properties. The main objective of the present systematic review was to assess the current evidence on the role of pharmacological mechanisms in the treatment of viral infections.

methodsThis study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, "iron chelators" and "viral infection", was employed.

resultsAccording to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections

conclusionNatural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.

Indexed as

Iron Chelating AgentsVirus DiseasesAnimalsAntiviral AgentsHumansAntiviral AgentsIron Chelating AgentsIron chelatorsmechanisms.safetytherapeutic potentialviral diseaseswider range

Identifiers

PMID38321902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.