Evidence map›Paper›PMID 38323082›Full record

ArticleFrontiers in pharmacology2024

Polymeric nanoparticles containing kojic acid induce structural alterations and apoptosis-like death in

Poliana Queiroz-Souza, Adan Galue-Parra, Lienne Silveira Moraes, Caroline Gomes Macedo, Ana Paula Drummond Rodrigues, Victor H S Marinho, Fabricio H Holanda, Irlon M Ferreira, Edilene Oliveira da Silva

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Poliana Queiroz-SouzaLaboratory of Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Pará, Brazil.
Adan Galue-ParraNational Institute of Science and Technology in Structural Biology and Bioimaging, Rio de Janeiro, Brazil.
Lienne Silveira MoraesLaboratory of Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Pará, Brazil.
Caroline Gomes MacedoLaboratory of Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Pará, Brazil.
Ana Paula Drummond RodriguesLaboratory of Electron Microscopy, Department of Health Surveillance, Ministry of Health, Evandro Chagas Institute, Belém, Pará, Brazil.
Victor H S MarinhoLaboratory of Biocatalysis and Applied Organic Synthesis, Federal University of Amapá, Macapá, Amapá, Brazil.
Fabricio H HolandaLaboratory of Biocatalysis and Applied Organic Synthesis, Federal University of Amapá, Macapá, Amapá, Brazil.
Irlon M FerreiraLaboratory of Biocatalysis and Applied Organic Synthesis, Federal University of Amapá, Macapá, Amapá, Brazil.
Edilene Oliveira da SilvaLaboratory of Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Pará, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis encompasses a cluster of neglected tropical diseases triggered by kinetoplastid phatogens belonging to the genus Leishmania. Current therapeutic approaches are toxic, expensive, and require long-term treatment. Nanoparticles are emerging as a new alternative for the treatment of neglected tropical diseases. Silk Fibroin is a biocompatible and amphiphilic protein that can be used for formulating nanoemulsions, while kojic acid is a secondary metabolite with antileishmanial actions. Thus, this study evaluated the efficacy of a nanoemulsion, formulated with silk fibroin as the surfactant and containing kojic acid (NanoFKA), against promastigote and amastigote forms of

Indexed as

drug delivery systemkojic acidleishmanicidal activitynanoparticlesilk fibroin

Identifiers

PMID38323082
PMCPMC10844493

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.