Evidence map›Paper›PMID 38324106›Full record

ArticleEndocrine2024

Peptide receptor radionuclide therapy with 177Lu- or 90Y-SSTR peptides in malignant pheochromocytomas (PCCs) and paragangliomas (PGLs): results from a single institutional retrospective analysis.

Manila Rubino, Giuseppe Danilo Di Stasio, Lisa Bodei, Stefano Papi, Paola Anna Rocca, Mahila Esmeralda Ferrari, Cristiana Iuliana Fodor, Vincenzo Bagnardi, Samuele Frassoni, Riccardo Mei and 3 more

Abstract read
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. A novel germline (c.314T>A)Frontiers in endocrinology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manila Rubino *Onco-Endocrinology Unit, IEO European Institute of Oncology IRCCS, Milano, Italy.
Giuseppe Danilo Di Stasio *Nuclear Medicine Service, Check-Up Polydiagnostic Center, Salerno, Italy.
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stefano PapiDivision of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milano, Italy.
Paola Anna RoccaDivision of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milano, Italy.
Mahila Esmeralda FerrariMedical Physics Unit, IEO European Institute of Oncology IRCCS, Milano, Italy.
Cristiana Iuliana FodorDivision of Radiotherapy, Data Management, IEO European Institute of Oncology IRCCS, Milano, Italy.
Vincenzo BagnardiDepartment of Statistics and Quantitative Methods, University of Milan-Bicocca, Milano, Italy.
Samuele FrassoniDepartment of Statistics and Quantitative Methods, University of Milan-Bicocca, Milano, Italy.
Riccardo MeiDivision of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milano, Italy.
Nicola FazioDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumours, IEO European Institute of Oncology, IRCCS, Milano, Italy.
Francesco CeciDivision of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milano, Italy.
Chiara Maria GranaRadiometabolic Therapy Unit, Division of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milano, Italy. chiara.grana@ieo.it.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundMalignant pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare tumors and available systemic therapies are limited.

aimTo explore the role of peptide receptor radionuclide therapy (PRRT) with Yttrium-90 (

methodsWe retrospectively analyzed more than 1500 patients with histologically proven neuroendocrine tumors treated with

resultsThirty (n = 30) patients were treated: 22 with PGLs and 8 with PCCs (12 M and 18 F, median age 47 [IQR: 35-60 years]). Eighteen patients (n = 18) had head and neck PGLs, 3 patients thoracic PGLs and 1 patient abdominal PGL. Sixteen patients (53%) had locally advanced and fourteen (47%) had metastatic disease. Twenty-seven (90%) patients had disease progression at baseline. Four (13%) patients were treated with

conclusionPRRT with

Indexed as

Adrenal Gland NeoplasmsLutetiumParagangliomaPheochromocytomaRadioisotopesAdultAgedFemaleHumansMaleMiddle AgedOctreotideRadiopharmaceuticalsReceptors, PeptideReceptors, SomatostatinRetrospective StudiesLutetiumLutetium-177OctreotideRadioisotopesRadiopharmaceuticalsReceptors, PeptideReceptors, SomatostatinYttrium RadioisotopesParagangliomaPheochromocytomaPRRTSomatostatin Receptors

Identifiers

PMID38324106
PMCPMC12054632

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.