Evidence map›Paper›PMID 38326458›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

Brain connectivity changes to fast versus slow dopamine increases.

Peter Manza, Dardo Tomasi, Leah Vines, Diana Sotelo, Michele-Vera Yonga, Gene-Jack Wang, Nora D Volkow

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03326245 (Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03326245 phase1completednot on this map

Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

TypeinterventionalSponsorNational Institute on Alcohol Abuse and Alcoholism (NIAAA)Ran2018 to 2024Enrolled25ConditionsNormal PhysiologyArmsMethylphenidate Pill, Oral Placebo, Intravenous Placebo, Intravenous methylphenidate
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  3. Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  4. Brain connectivity changes to fast versus slow dopamine increases.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Peter ManzaNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. peter.manza@nih.gov.ORCID http://orcid.org/0000-0002-0791-357X
Dardo TomasiNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0183-5678
Leah VinesNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Diana SoteloNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Michele-Vera YongaNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Gene-Jack WangNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5017-9905
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. nora.volkow@nih.gov.
National Institutes of Health · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Intramural NIH HHS ZIA AA000550
6 · The paper itself

Abstract

The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet how the rate of drug-induced dopamine increases impacts brain network communication remains unresolved. We manipulated route of MP administration to generate fast versus slow dopamine increases. We hypothesized that fast versus slow dopamine increases would result in a differential pattern of global brain connectivity (GBC) in association with regional levels of dopamine D1 receptors, which are critical for drug reward. Twenty healthy adults received MP intravenously (0.5 mg/kg; fast dopamine increases) and orally (60 mg; slow dopamine increases) during simultaneous [

Indexed as

BrainDopamineMagnetic Resonance ImagingMethylphenidatePositron-Emission TomographyRacloprideAdultBrain MappingCentral Nervous System StimulantsDopamine AntagonistsDouble-Blind MethodFemaleHumansMaleNeural PathwaysReceptors, Dopamine D1Central Nervous System StimulantsDopamineDopamine AntagonistsMethylphenidateRacloprideReceptors, Dopamine D1

Identifiers

PMID38326458
PMCPMC11039764
OpenAlexW4391595153

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.