Evidence map›Paper›PMID 38328196›Full record

ArticlebioRxiv : the preprint server for biology2024

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.

Jia He, Adriana Blazeski, Uthayanan Nilanthi, Javier Menéndez, Samuel C Pirani, Daniel S Levic, Michel Bagnat, Manvendra K Singh, José G Raya, Guillermo García-Cardeña and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jia HeDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Adriana BlazeskiCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA and Harvard Medical School, Boston, MA, USA.
Uthayanan NilanthiProgramme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, Singapore, 169857.
Javier MenéndezDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Samuel C PiraniDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Daniel S LevicDepartment of Cell Biology, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-0240-5178
Michel BagnatDepartment of Cell Biology, Duke University, Durham, NC 27710, USA.
Manvendra K SinghProgramme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, Singapore, 169857.ORCID 0000-0002-2884-0074
José G RayaDepartment of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Guillermo García-CardeñaCenter for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA and Harvard Medical School, Boston, MA, USA.
Jesús Torres-VázquezDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-3808-3978
New York University · USBroad Institute · USDuke-NUS Medical School · SGDuke University · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Nancy Chan · 1985 to 2026
$83.1M
Organ Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5M
Mechanistic bases of vessel diameter regulation by Plexind1 - ResubmissionR01HL161090 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TORRES-VÁZQUEZ, JESÚS · 2022 to 2025
$3.0M
Developmental regulation of epithelial polarization by pre-mRNA splicingR01DK132120 · NIDDK · DUKE UNIVERSITY · PI Michel Bagnat · 2023 to 2026
$1.8M
Flow-dependent endothelial cell signalingR21HL152367 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARCIA-CARDENA, GUILLERMO · 2020 to 2021
$492k
Zeiss LSM 710 confocal microscopeS10RR024708 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NANCE, JEREMY · 2009 to 2009
$438k
NCI NIH HHS P30 CA016087NCRR NIH HHS S10 RR024708NHLBI NIH HHS R01 HL161090NHLBI NIH HHS R21 HL152367NIBIB NIH HHS T32 EB016652NIDDK NIH HHS R01 DK132120
6 · The paper itself

Abstract

The cardiovascular system generates and responds to mechanical forces. The heartbeat pumps blood through a network of vascular tubes, which adjust their caliber in response to the hemodynamic environment. However, how endothelial cells in the developing vascular system integrate inputs from circulatory forces into signaling pathways to define vessel caliber is poorly understood. Using vertebrate embryos and

Indexed as

artificial human vascular networkblood flowendothelial cellsKlf2mousePlexinD1vessel caliberzebrafish

Identifiers

PMID38328196
PMCPMC10849625
OpenAlexW4391238828

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.