Evidence map›Paper›PMID 38330641›Full record

ArticleNeurobiology of aging2024

The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment.

Belfin Robinson, Shankar Bhamidi, Eran Dayan, Alzheimer's Disease Neuroimaging Initiative

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Belfin RobinsonBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Shankar BhamidiDepartment of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Eran DayanBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: eran_dayan@med.unc.edu.
Alzheimer's Disease Neuroimaging Initiative
University of North Carolina at Chapel Hill · USImaging Center · US

Funding

Redundancy as a neuroprotective mechanism against aging-related cognitive declineR01AG062590 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYAN, ERAN · 2019 to 2022
$1.6M
National Science Foundation DMS-2113662National Science Foundation DMS-2134107NIA NIH HHS R01 AG062590
6 · The paper itself

Abstract

Synergies between amyloid-β (Aβ), tau, and neurodegeneration persist along the Alzheimer's disease (AD) continuum. This study aimed to evaluate the extent of spatial coupling between tau and neurodegeneration (atrophy) and its relation to Aβ positivity in mild cognitive impairment (MCI). Data from 409 participants were included (95 cognitively normal controls, 158 Aβ positive (Aβ+) MCI, and 156 Aβ negative (Aβ-) MCI). Florbetapir PET, Flortaucipir PET, and structural MRI were used as biomarkers for Aβ, tau and atrophy, respectively. Individual correlation matrices for tau load and atrophy were used to layer a multilayer network, with separate layers for tau and atrophy. A measure of coupling between corresponding regions of interest (ROIs) in the tau and atrophy layers was computed, as a function of Aβ positivity. Fewer than 25% of the ROIs across the brain showed heightened coupling between tau and atrophy in Aβ+ , relative to Aβ- MCI. Coupling strengths in the right rostral middle frontal and right paracentral gyri, in particular, mediated the association between Aβ burden and cognition in this sample.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesAtrophyBiomarkersHumansPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer’s diseaseAtrophyMultilayer networksTau

Identifiers

PMID38330641
PMCPMC10940182
OpenAlexW4391484910

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.