Evidence map›Paper›PMID 38334643›Full record

ArticleCells2024

Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change.

Boglárka Emese Skopkó, Judit Rita Homoki, Mónika Éva Fazekas, Melinda Paholcsek, Péter Fauszt, Péter Dávid, László Stündl, Piroska Bíróné Molnár, Ildikó Noémi Forgács, Judit Váradi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Boglárka Emese SkopkóDepartment of Dentoalveolar Surgery, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1561-4956
Judit Rita HomokiInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Mónika Éva FazekasInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Melinda PaholcsekInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Péter FausztInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Péter DávidInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-6451-1200
László StündlInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-9839-0905
Piroska Bíróné MolnárInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Ildikó Noémi ForgácsInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.
Judit VáradiDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1885-164X
Kinga Ágnes BágyiDepartment of Operative Dentistry and Endodontics, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
Judit RemenyikInstitute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1321-0907
University of Debrecen · HU

Funding

Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund TKP2021-NKTA-32
6 · The paper itself

Abstract

backgroundOur previous studies demonstrated that sour cherry anthocyanins (AC) reduce the salivary count of

methodsThe study was conducted over three weeks with two groups; young adults (18-30) and adults (30-45). Ten participants changed their toothbrushes, while the other 10 participants did not change after the control period. After scaling, all participants received three doses of AC gum daily. The salivary mRNA and protein levels of cytokines, mucins, melatonin, and the microbiota of unstimulated and stimulated saliva were determined by polymerase chain reaction, enzyme-linked immunosorbent assay, and 16S rRNA gene sequencing.

resultsSignificantly higher levels of tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), mucin5B (MUC5B), mucin7 (MUC7), and melatonin were detected in stimulated saliva. Correlation analysis of these factors with the microbiota showed positive correlations with the genera

conclusionsAC chewing gum has a beneficial effect on the composition of the oral microbiome, and toothbrush replacement leads to changes in the levels of salivary pro-inflammatory cytokines.

Indexed as

MelatoninPrunus aviumAnthocyaninsChewing GumCytokinesHumansRNA, Ribosomal, 16SSalivaYoung AdultAnthocyaninsChewing GumCytokinesMelatoninRNA, Ribosomal, 16SanthocyaninInterleukin-1βMucin5BMucin7oral microbiometoothbrush changetumor necrosis factor α

Identifiers

PMID38334643
PMCPMC10854574
OpenAlexW4391309570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.