ArticleScience advances2024
Functional
Open access · goldAbstract readComparative Study
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
18.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 33 citations in OpenAlex.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Genomic Evidence for Natural Selection Underlying High-Altitude Adaptive Hemoglobin Levels Among Peruvian Andeans.Genome biology and evolution · 2026Article
- Is altitude-induced polycythaemia an unintended evolutionary mistake?Experimental physiology · 2026Article
- Advancing high-altitude medicine: a model for the future.Signal transduction and targeted therapy · 2026Review
- Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude.Cell metabolism · 2026Article
- Salutogenomics: embracing the full spectrum of human health.Trends in genetics : TIG · 2026Review
- Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.Experimental physiology · 2026Review
- Genetic insights into the peoples who shaped the American continent.Genetics and molecular biology · 2026Article
- Effects and adaptation of high-altitude hypoxia on lipid metabolism: mechanisms and health implications.Frontiers in physiology · 2026Review
- Detrimental Effects of Hypoxia on Cognitive Function: Adaptations, Challenges, and Resilience in Andean Populations.Journal of racial and ethnic health disparities · 2025Article
- Dysregulated Fatty Acid Metabolism in Preeclampsia Among Highland Andeans: Insights Into Adaptive and Maladaptive Placental Metabolic Phenotypes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases.Human genomics · 2025Review
- Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- AdaptiveiScience · 2025Article
- Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice.Nature communications · 2025Article
- Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α.Communications biology · 2025Article
- Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.Cancer discovery · 2025Article
- Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations.Communications biology · 2025Article
- Evolution, genetic diversity, and health.Nature medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 10 institutions in 6 countries.
Elijah S LawrenceDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-7656-0600
Wanjun GuDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7342-7000
Ryan J BohlenderDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-6347-0494
Cecilia Anza-RamirezLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0001-7364-8252
Amy M ColeSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
James J YuDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9967-8449
Hao HuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Erica C HeinrichDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-6861-6165
Katie A O'BrienDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Carlos A VasquezDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-1965-8457
Quinn T CowanDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8697-8178
Patrick T BruckDepartment of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8278-3904
Kysha MercaderDepartment of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9021-0591
Mona AlotaibiDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8492-9930
Tao LongDepartment of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7052-9546
James E HallDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9843-7520
Esteban A MoyaDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9243-5057
Marco A BaukDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5977-4981
Jennifer J ReevesDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0002-7325-1751
Mitchell C KongDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-1657-7934
Rany M SalemHerbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8816-6862
Gustavo Vizcardo-GalindoLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0002-8131-8808
Jose-Luis MacarlupuLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
Rómulo Figueroa-MujícaLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
Daniela BermudezLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0001-7879-0485
Noemi CoranteLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0003-0083-7380
Eduardo GaioLaboratório de Fisiologia Respiratória, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.ORCID 0000-0001-9621-2443
Keolu P FoxDepartment of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4215-5273
Veikko SalomaaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7563-5324
Aki S HavulinnaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0002-4787-8959
Andrew J MurrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.ORCID 0000-0002-0929-9315
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Frank L PowelDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5166-4347
Mohit JainDepartment of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Alexis C KomorDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5043-0998
Gianpiero L CavalleriSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-9802-0506
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-1100-9364
Francisco C VillafuerteLaboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0003-0731-8911
Tatum S SimonsonDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4062-2587
University of California System · USUniversity of California San Diego · USUniversidad Peruana Cayetano Heredia · PEThe University of Texas MD Anderson Cancer Center · USFinnish Institute for Health and Welfare · FIRoyal College of Surgeons in Ireland · IEUniversity of Cambridge · GBHuman Longevity (United States) · USUniversidade de Brasília · BRUniversity of California, Riverside · US
Funding
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MThe cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1MVentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9MUC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6MRespiratory and genomic contributions to adaptive/maladaptive hypoxia responsesR01HL145470 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2019 to 2023
$2.4MTraining in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1MNHLBI NIH HHS R01 HL145470NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL134632NIGMS NIH HHS T32 GM145427NIGMS NIH HHS T32 GM145449Wellcome Trust
Abstract
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species.
Indexed as
Adaptation, PhysiologicalAltitudeHematocritSouth American PeopleEast Asian PeopleEndothelial PAS Domain-Containing Protein 1HumansHypoxiaMutation, MissenseEndothelial PAS Domain-Containing Protein 1
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.