ArticleNature metabolism2024
Hypermetabolism and energetic constraints in mitochondrial disorders.
Open access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.Research square · 2026Article
- The Energetic Cost of Adrenergic Signaling in Primary Human Fibroblasts.bioRxiv : the preprint server for biology · 2026Article
- Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.bioRxiv : the preprint server for biology · 2026Article
- Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.Redox biology · 2026Article
- NADThe EMBO journal · 2026Article
- Targeting mitochondrial deubiquitinase USP30 to induce mitophagy in heteroplasmic mitochondrial diseases.Pharmacological reports : PR · 2026Article
- Article
- Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions.Frontiers in integrative neuroscience · 2026Review
- The microRNA miR-71 suppresses maladaptive UPRNature communications · 2025Article
- Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency.Communications biology · 2025Article
- Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.Nature communications · 2025Article
- The energy resistance principle.Cell metabolism · 2025Review
- The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model.NPJ Parkinson's disease · 2025Article
- Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.Cell reports. Medicine · 2025Review
- Mitochondrial Energy Transformation Capacity Influences Brain Activation During Sensory, Affective, and Cognitive Tasks.bioRxiv : the preprint server for biology · 2025Article
- Mitochondria-centred metabolomic map of inclusion body myositis: sex-specific alterations in central carbon metabolism.Annals of the rheumatic diseases · 2025Article
- Intrinsic health as a foundation for a science of health.Science advances · 2025Review
- Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Alexander J SercelDepartment of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, USA.ORCID http://orcid.org/0000-0002-0749-2162
Gabriel SturmDepartment of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, USA.ORCID http://orcid.org/0000-0002-7280-4310
Dympna GallagherDepartment of Medicine, Columbia University Irving Medical Center, New York, USA.
Marie-Pierre St-OngeDivision of General Medicine and Center of Excellence for Sleep & Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, USA.
Christopher P KempesThe Santa Fe Institute, New Mexico, USA.
Herman PontzerDepartment of Evolutionary Anthropology, Duke University, North Carolina, USA.ORCID http://orcid.org/0000-0003-2397-6543
Michio HiranoDepartment of Neurology, H. Houston Merritt Center, Columbia University Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, USA.ORCID http://orcid.org/0000-0002-7070-7402
Martin PicardDepartment of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, USA. martin.picard@columbia.edu.ORCID http://orcid.org/0000-0003-2835-0478
Columbia University Irving Medical Center · USCircadian (United States) · USColumbia University · USDuke University · USSanta Fe Institute · USUniversity of California, San Francisco · US
Funding
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0MThe North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAAS, RICHARD H · 2011 to 2023
$17.5MMechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic healthR35HL155670 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARIE-PIERRE ST-ONGE · 2021 to 2026
$5.4MMitochondrial regulation of stress reactivity in humansR01MH122706 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2020 to 2024
$3.8MImpact of circadian misalignment on energy balance regulationR01HL142648 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ST-ONGE, MARIE-PIERRE · 2018 to 2022
$3.8MTransduction of Psychological Stress into Systematic Inflammation by Mitochondrial DNA SignalingR01MH119336 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAUFMAN, BRETT A, MARSLAND, ANNA L · 2019 to 2023
$3.4MMetabolic regulation of human DNA methylation clocksR01AG066828 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PICARD, MARTIN · 2020 to 2024
$3.2MNHLBI NIH HHS R01 HL142648NHLBI NIH HHS R35 HL155670NIA NIH HHS R01 AG066828NIDDK NIH HHS P30 DK026687NIMH NIH HHS R01 MH119336NIMH NIH HHS R01 MH122706NINDS NIH HHS U54 NS078059
Abstract
PubMed holds no abstract for this paper.
Indexed as
Mitochondrial DiseasesHumansMitochondria
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.