Evidence mapPaperPMID 38337656Full record

ArticleNutrients2024

Olive (

Martina Bartolomei, Jianqiang Li, Anna Laura Capriotti, Melissa Fanzaga, Lorenza d'Adduzio, Aldo Laganà, Andrea Cerrato, Nadia Mulinacci, Lorenzo Cecchi, Carlotta Bollati and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Martina BartolomeiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-3851-3392
Jianqiang LiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-9885-3065
Anna Laura CapriottiDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Melissa FanzagaDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0009-0002-3175-924X
Lorenza d'AdduzioDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-3356-0595
Aldo LaganàDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4963-3020
Andrea CerratoDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6625-8782
Nadia MulinacciDepartment of Neuroscience, Psychology, Drug and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Florence, Italy.ORCID 0000-0001-7873-5259
Lorenzo CecchiDepartment of Agricultural, Food, Environmental and Forestry Sciences and Technologies, University of Florence, Via Donizetti, 50144 Florence, Italy.ORCID 0000-0002-9332-704X
Carlotta BollatiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5698-1325
Carmen LammiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-7428-4486
University of Milan · ITSapienza University of Rome · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of olive oil has important economic repercussions in Mediterranean countries but also a considerable impact on the environment. This production generates enormous quantities of waste and by-products, which can be exploited as new raw materials to obtain innovative ingredients and therefore make the olive production more sustainable. In a previous study, we decided to foster olive seeds by generating two protein hydrolysates using food-grade enzymes, alcalase (AH) and papain (PH). These hydrolysates have shown, both in vitro and at the cellular level, antioxidant and antidiabetic activities, being able to inhibit the activity of the DPP-IV enzyme and modulate the secretion of GLP-1. Given the multifunctional behavior of peptides, both hydrolysates displayed dual hypocholesterolemic activity, inhibiting the activity of HMGCoAR and impairing the PPI of PCSK9/LDLR, with an IC

Indexed as

OleaProprotein Convertase 9Caco-2 CellsCholesterolHep G2 CellsHumansPeptidesSeedsCholesterolPCSK9 protein, humanPeptidesProprotein Convertase 9cholesterol metabolismfood bioactive peptidesLDLRmultifunctional peptidesPCSK9

Identifiers

PMID38337656
PMCPMC10857614
OpenAlexW4391252219

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.