Evidence map›Paper›PMID 38337678›Full record

ReviewNutrients2024

Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases.

Hesham R El-Seedi, Suzy Salama, Aida A Abd El-Wahed, Zhiming Guo, Alessandro Di Minno, Maria Daglia, Chuan Li, Xiao Guan, Daniele Giuseppe Buccato, Shaden A M Khalifa and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Hesham R El-SeediPharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, P.O. Box 591, SE-751 24 Uppsala, Sweden.ORCID 0000-0002-2519-6690
Suzy SalamaIndigenous Knowledge and Heritage Center, Ghibaish College of Science and Technology, Ghibaish 51111, Sudan.ORCID 0000-0003-0430-1436
Aida A Abd El-WahedDepartment of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt.ORCID 0000-0002-2200-3507
Zhiming GuoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0001-6416-7457
Alessandro Di MinnoDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-8084-9976
Maria DagliaDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-4870-7713
Chuan LiSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.ORCID 0000-0002-5612-522X
Xiao GuanSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Daniele Giuseppe BuccatoDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Shaden A M KhalifaPsychiatry and Neurology Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden.
Kai WangState Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.ORCID 0000-0003-0553-5293
Ceinge Biotecnologie Avanzate (Italy) · ITJiangsu University · CNAgricultural Research Center · EGChinese Academy of Agricultural Sciences · CNHainan University · CNSaint Göran Hospital · SEUniversity of Naples Federico II · ITUniversity of Shanghai for Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review's focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the "Queen bee acid," show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ's role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ's therapeutic effects.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, ExperimentalGastrointestinal DiseasesMetabolic DiseasesAnimalsAnti-Inflammatory AgentsBeesFatty AcidsRatsRoyal JellyAnti-Inflammatory AgentsFatty AcidsRoyal Jellybioactive compoundscardiovascular diseasesdiabetes mellitusgastrointestinal diseasesroyal jelly

Identifiers

PMID38337678
PMCPMC10856930
OpenAlexW4391309556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.