Evidence map›Paper›PMID 38338741›Full record

ArticleInternational journal of molecular sciences2024

The Application of Peptide Nucleic Acids (PNA) in the Inhibition of Proprotein Convertase Subtilisin/Kexin 9 (

Agnieszka Polak, Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Katarzyna Prochera, Oliwia Bujak, Piotr Mucha, Piotr Rekowski, Bogusław Okopień

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Detecting theBiomolecules · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Agnieszka PolakDepartment of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.ORCID 0000-0001-6436-8451
Grzegorz MachnikDepartment of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Łukasz BułdakDepartment of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.ORCID 0000-0002-2017-5516
Jarosław RuczyńskiLaboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-1945-194X
Katarzyna ProcheraLaboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Oliwia BujakLaboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Piotr MuchaLaboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-0269-8620
Piotr RekowskiLaboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Bogusław OkopieńDepartment of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.ORCID 0000-0001-7228-2906
University of Gdańsk · PLMedical University of Silesia · PL

Funding

Medical University of Silesia BNW-1-031/N/3/OUniveristy of Gdańsk DS-531-T064-D492-23
6 · The paper itself

Abstract

Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays a key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations of the

Indexed as

HypercholesterolemiaPCSK9 InhibitorsPeptide Nucleic AcidsGene ExpressionHumansProprotein Convertase 9Proprotein ConvertasesReceptors, LDLSubtilisinPCSK9 InhibitorsPCSK9 protein, humanPeptide Nucleic AcidsProprotein Convertase 9Proprotein ConvertasesReceptors, LDLSubtilisinantigene activitypeptide nucleic acids (PNA)proprotein convertase subtilisin/kexin 9 (PCSK9)transcriptiontranslation

Identifiers

PMID38338741
PMCPMC10855603
OpenAlexW4391229053

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.