Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine.

Jemima S A Dzator, Robert A Smith, Kirsten G Coupland, Peter R C Howe, Lyn R Griffiths

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jemima S A DzatorSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia.

Robert A SmithGenomics Research Centre, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD 4059, Australia.

Kirsten G CouplandSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0000-0002-4320-1043

Peter R C HoweSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0000-0001-6546-7742

Lyn R GriffithsGenomics Research Centre, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD 4059, Australia.ORCID 0000-0002-6774-5475

Queensland University of Technology · AUGriffith University · AUHunter Medical Research Institute · AUUniversity of Southern Queensland · AU

Funding

Evolva (Switzerland) G2000006

6 · The paper itself

Abstract

There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function, (2) differs between hormonal migraineur and non-migraineur women, and (3) changes following resveratrol supplementation. This study utilised data obtained from 87 women (59 hormonal migraineurs and 28 controls) where RNA from venous blood was used to quantify gene expression and transcranial Doppler ultrasound was used to evaluate cerebrovascular function. Spearman's correlation analyses were performed between gene expression, cerebrovascular function, and migraine-related disability. We compared the expression of genes associated with endothelial function between migraineurs and non-migraineurs, and between resveratrol and placebo. The expression of several genes related to endothelial function was associated with alterations in cerebrovascular function. Notably, the expression of

Indexed as

Migraine DisordersNeurovascular CouplingCerebrovascular CirculationFemaleHumansResveratrolUltrasonography, Doppler, TranscranialResveratrolcerebrovascularendothelial functiongene expressionhormonal migrainemigraineresveratrol

Identifiers

PMID38338971

DOI10.3390/ijms25031694

PMCPMC10855027

OpenAlexW4391361470

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.