Evidence map›Paper›PMID 38341137›Full record

SynthesisJournal of sport and health science2024

The anti-inflammatory effects of exercise on autoimmune diseases: A 20-year systematic review.

Beibei Luo, Dao Xiang, Xiaorong Ji, Xuan Chen, Rui Li, Shuxin Zhang, Yujun Meng, David C Nieman, Peijie Chen

Open access · diamondAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sport and health science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  18. Exercise pills for cardiometabolic health cannot mimic the exercise milieu.Trends in endocrinology and metabolism: TEM · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Beibei LuoSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; Shanghai Key Laboratory of Human Performance, Shanghai University of Sport, Shanghai 200438, China.
Dao XiangDepartment of Diving and Hyperbaric Medicine, Naval Medical Center, Shanghai 200433, China; National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Xiaorong JiSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Xuan ChenSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Rui LiSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Shuxin ZhangSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Yujun MengSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
David C NiemanHuman Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. Electronic address: niemandc@appstate.edu.
Peijie ChenSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; Research Institute for Doping Control, Shanghai University of Sport, Shanghai 200438, China. Electronic address: chenpeijie@sus.edu.cn.
Shanghai University of Sport · CNAppalachian State University · USNaval University of Engineering · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune diseases. The aim of this systematic review was to examine the evidence on the role of exercise training in mitigating inflammation in adolescents and adults with autoimmune disease.

methodsPubMed, Web of Science, and Embase databases were systematically reviewed for related studies published between January 1, 2003, and August 31, 2023. All randomized and non-randomized controlled trials of exercise interventions with autoimmune disease study participants that evaluated inflammation-related biomarkers were included. The quality of evidence was assessed using the Tool for the assEssment of Study qualiTy and reporting in EXercise scale and Cochrane bias risk tool.

resultsA total of 14,565 records were identified. After screening the titles, abstracts, and full texts, 87 were eligible for the systematic review. These studies were conducted in 25 different countries and included a total of 2779 participants (patients with autoimmune disease, in exercise or control groups). Overall, the evidence suggests that inflammation-related markers such as C-reactive protein, interleukin 6, and tumor necrosis factor α were reduced by regular exercise interventions. Regular exercise interventions combined with multiple exercise modes were associated with greater benefits.

conclusionRegular exercise training by patients with autoimmune disease exerts an anti-inflammatory influence. This systematic review provides support for the promotion and development of clinical exercise intervention programs for patients with autoimmune disease. Most patients with autoimmune disease can safely adopt moderate exercise training protocols, but changes in inflammation biomarkers will be modest at best. Acute exercise interventions are ineffective or even modestly but transiently pro-inflammatory.

Indexed as

Autoimmune DiseasesBiomarkersInflammationAdolescentAdultC-Reactive ProteinExerciseExercise TherapyHumansInterleukin-6Tumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alphaAutoimmune diseasesCytokinesInflammationPhysical activityTraining

Identifiers

PMID38341137
PMCPMC11117003
OpenAlexW4391691305

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.