Evidence map›Paper›PMID 38341414›Full record

ReviewTranslational psychiatry2024

Elevating the field for applying neuroimaging to individual patients in psychiatry.

David R Roalf, Martijn Figee, Desmond J Oathes

Abstract readReview
In one paragraph

Review in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  7. Review
  8. Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  9. Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David R RoalfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1728-9782
Martijn FigeeNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3679-284X
Desmond J OathesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. oathes@pennmedicine.upenn.edu.ORCID 0000-0001-7346-2669

Funding

Ultra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8M
Connectomic Deep Brain Stimulation for Obsessive Compulsive DisorderR01MH123542 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHOI, KI SUENG, FIGEE, MARTIJN · 2021 to 2025
$3.7M
Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5M
Individualized Closed Loop TMS for Working Memory EnhancementR01MH120811 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG, OATHES, DESMOND · 2019 to 2023
$3.5M
Network Control and Functional Context: Mechanisms for TMS ResponseRF1MH116920 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, OATHES, DESMOND · 2018 to 2018
$2.8M
NIMH NIH HHS R01 MH119185NIMH NIH HHS R01 MH120174NIMH NIH HHS R01 MH120811NIMH NIH HHS R01 MH123542NIMH NIH HHS RF1 MH116920U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH116920U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH119185U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH120174U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH120811U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH123542-01A1
6 · The paper itself

Abstract

Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability in response to treatment. Neuroimaging may also be particularly suited to the science of brain stimulation interventions in psychiatry given that imaging can both inform brain targeting as well as measure changes in brain circuit communication as a function of how effectively interventions improve symptoms. We argue that a greater focus on individual patient imaging data will pave the way to stronger relevance to clinical care in psychiatry. We also stress the importance of using imaging in symptom-relevant experimental manipulations and how relevance will be best demonstrated by pairing imaging with differential treatment prediction and outcome measurement. The priorities for using brain imaging to inform psychiatry may be shifting, which compels the field to solidify clinical relevance for individual patients over exploratory associations and biomarkers that ultimately fail to replicate.

Indexed as

Mental DisordersPsychiatryBrainHumansMagnetic Resonance ImagingNeuroimaging

Identifiers

PMID38341414
PMCPMC10858949

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.